Serotonin 5-HT(2) and 5-HT(1A)-like receptors differentially modulate aggressive behaviors in Drosophila melanogaster.
Serotonin 5-HT(2) and 5-HT(1A)-like receptors differentially modulate aggressive behaviors in Drosophila melanogaster.
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DOI：
10.1016/j.neuroscience.2008.10.055
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发表时间：
2009-02-18
期刊：
影响因子：
3.3
通讯作者：
Nichols CD
中科院分区：
文献类型：
--
作者：
Johnson O;Becnel J;Nichols CD
Aggressive behavior is widespread throughout the animal kingdom, and is a complex social behavior influenced by both genetics and environment. Animals typically fight over resources that include food, territory, and sexual partners. Of all the neurotransmitters, serotonin has been the most implicated in modulating aggressive behaviors in mammalian systems. In the fruit fly, Drosophila melanogaster, the involvement of serotonin itself in aggressive behaviors has been recently established, however, the underlying mechanisms have largely remained elusive. Here we describe the influence of different serotonin receptor subtypes on aggressive behaviors in Drosophila. Drosophila express homologs of three mammalian serotonin receptors: the 5-HT1A, 5-HT2, and 5-HT7 receptors. Significantly, these receptors mediate important behaviors in mammalian systems ranging from feeding, aggression, and sleep, to cognition. To examine the role of the 5-HT2Dro receptor, we utilized the selective 5-HT2 receptor agonist (R)-1-[2,5-dimethoxy-4-iodophenyl]-2-aminopropane (DOI), and the 5-HT2 receptor antagonist, ketanserin. To examine the role of 5-HT1A-like receptors we used the 5-HT1A receptor agonist 8-hydroxy-2-dipropylaminotetralin hydrobromide (8-OH-DPAT), and the 5-HT1A receptor antagonist WAY100635. We find that activation of 5-HT2 receptors with (R)-DOI appears to decrease overall aggression, whereas activation of 5-HT1A-like receptors with 8-OH-DPAT increases overall aggression. Furthermore, the different serotonin receptor circuitries appear to mediate different aspects of aggression: 5-HT2 receptor manipulation primarily alters lunging and boxing, whereas 5-HT1A-like receptor manipulation primarily affects wing threats and fencing. Elucidating the effects of serotonergic systems on aggression in the fly is a significant advancement not only in establishing the fly as a system to study aggression, but as a system relevant to elucidating molecular mechanisms underlying aggression in mammals, including humans.
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影响因子：
3.3
作者：
Nichols, CD;Ronesi, J;Sanders-Bush, E
通讯作者：
Sanders-Bush, E
多巴胺水平的增加增强了果蝇的雄性求爱。
影响因子：
5.3
作者：
Liu, Tong;Dartevelle, Laurence;Guo, Aike
通讯作者：
Guo, Aike
影响因子：
2.6
作者：
JACOBS, ME
通讯作者：
JACOBS, ME
影响因子：
2.5
作者：
HOFFMANN, AA
通讯作者：
HOFFMANN, AA
影响因子：
2.9
作者：
Hassanain, M;Bhatt, S;Siegel, A
通讯作者：
Siegel, A