Aurora-A identifies early recurrence and poor prognosis and promises a potential therapeutic target in triple negative breast cancer.
Aurora-A identifies early recurrence and poor prognosis and promises a potential therapeutic target in triple negative breast cancer.
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Aurora-A 可识别早期复发和不良预后，有望成为三阴性乳腺癌的潜在治疗靶点
DOI：
10.1371/journal.pone.0056919
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Liu Q
中科院分区：
文献类型：
--
作者：
Xu J;Wu X;Zhou WH;Liu AW;Wu JB;Deng JY;Yue CF;Yang SB;Wang J;Yuan ZY;Liu Q
三阴性乳腺癌（TNBC）预后不良，成为乳腺癌治疗的重大挑战。在本研究中，对 122 名 TNBC 患者进行了 Aurora-A (Aur-A) 表达和生存预后分析。我们发现Aur-A高表达与TNBC患者的初始临床分期（P = 0.025）、增殖标志物Ki-67（P = 0.001）和复发率呈正相关（P<0.001）。在Aur-A高表达的TNBC患者中，远处复发的风险在前3年达到峰值，此后迅速下降，而Aur-A低表达的患者在整个随访期间表现出相对恒定的复发风险。单变量和多变量分析表明，Aur-A 的过度表达预示着 TNBC 患者总生存期较差 (P = 0.002) 和无进展生存期 (P = 0.012)。此外，与 Aur-A 和 Ki-67 的低表达相比，与高 Ki-67 相关的 Aur-A 过度表达预示预后较差。重要的是，我们进一步发现Aur-A在TNBC细胞中过度表达，抑制该激酶可抑制TNBC细胞增殖并阻止细胞迁移。我们的研究结果表明，Aur-A 是 TNBC 的潜在治疗靶点，而抑制 Aur-A 激酶是 TNBC 癌症治疗的一种有前途的方案。
Triple negative breast cancer (TNBC) acquires an unfavorable prognosis, emerging as a major challenge for the treatment of breast cancer. In the present study, 122 TNBC patients were subjected to analysis of Aurora-A (Aur-A) expression and survival prognosis. We found that Aur-A high expression was positively associated with initial clinical stage (P = 0.025), the proliferation marker Ki-67 (P = 0.001), and the recurrence rate of TNBC patients (P<0.001). In TNBC patients with Aur-A high expression, the risk of distant recurrence peaked at the first 3 years and declined rapidly thereafter, whereas patients with Aur-A low expression showed a relatively constant risk of recurrence during the entire follow-up period. Univariate and multivariate analysis showed that overexpression of Aur-A predicted poor overall survival (P = 0.002) and progression-free survival (P = 0.012) in TNBC. Furthermore, overexpression of Aur-A, associated with high Ki-67, predicted an inferior prognosis compared with low expression of both Aur-A and Ki-67. Importantly, we further found that Aur-A was overexpressed in TNBC cells, and inhibition of this kinase inhibited cell proliferation and prevented cell migration in TNBC. Our findings demonstrated that Aur-A was a potential therapeutic target for TNBC and inhibition of Aur-A kinase was a promising regimen for TNBC cancer therapy.
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影响因子：
254.7
作者：
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通讯作者：
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