Cerebral pressure passivity in newborns with encephalopathy undergoing therapeutic hypothermia.

Cerebral pressure passivity in newborns with encephalopathy undergoing therapeutic hypothermia.
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DOI:
10.3389/fnhum.2014.00266
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发表时间:
2014
影响因子:
2.9
通讯作者:
du Plessis A
du Plessis A
中科院分区:
医学3区
文献类型:
--
作者:
Govindan RB;Massaro AN;Andescavage NN;Chang T;du Plessis A

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我们扩展了我们最近修改的功率谱估计方法来量化频谱相干性。我们在模拟数据上测试了标准方法和修改后的方法,结果表明,修改后的方法对模拟中引入的耦合具有高度的特异性和敏感性,而标准方法缺乏这些功能。我们还应用改进的和标准的方法来量化的压力被动在4个婴儿接受治疗性低温。这是通过测量连续脑血红蛋白差异和平均动脉血压之间的耦合来完成的。我们的结果表明,改进的方法确定了一个较低的压力被动指数(PPI,百分比时间的相干性高于预定义的阈值)比标准的方法(P = 0.0027)。
We extended our recent modification of the power spectral estimation approach to quantify spectral coherence. We tested both the standard and the modified approaches on simulated data, which showed that the modified approach was highly specific and sensitive to the coupling introduced in the simulation while the standard approach lacked these features. We also applied the modified and standard approaches to quantify the pressure passivity in 4 infants receiving therapeutic hypothermia. This was done by measuring the coupling between continuous cerebral hemoglobin differences and mean arterial blood pressure. Our results showed that the modified approach identified a lower pressure passivity index (PPI, percent time the coherence was above a predefined threshold) than the standard approach (P = 0.0027).
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