Right inferior frontal gyrus theta-burst stimulation reduces smoking behaviors and strengthens fronto-striatal-limbic resting-state functional connectivity: a randomized crossover trial.
Right inferior frontal gyrus theta-burst stimulation reduces smoking behaviors and strengthens fronto-striatal-limbic resting-state functional connectivity: a randomized crossover trial.
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右下额回刺激刺激可减少吸烟行为，并增强额纹状体 - 纹状体静止状态功能连接性：一项随机交叉试验。
DOI：
10.3389/fpsyt.2023.1166912
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发表时间：
2023
影响因子：
4.7
通讯作者：
Froeliger, Brett
中科院分区：
文献类型：
--
作者：
Upton, Spencer;Brown, Alexander A. A.;Golzy, Mojgan;Garland, Eric L. L.;Froeliger, Brett
关键词：
右额下回（rIFG）的功能和解剖学不规则性，腹外侧前额叶区域，介导自上而下的抑制控制优势行为反应，涉及尼古丁依赖（ND）的持续维持。然而，很少有研究的rIFG的神经调节吸烟行为，抑制控制，和休息状态功能连接（rsFC）与ND的个人之间的影响。在这项双盲、交叉、θ波群刺激（TBS）研究中，ND成人患者（N = 31;女性：n = 15）完成了基线治疗，然后随机分配至两个功能神经导航TBS与rIFG的平衡治疗：第1天为连续TBS（cTBS），第2天为间歇TBS（iTBS）。评估了香烟渴望，吸烟和额-纹状体-边缘系统rsFC的差异。相对于基线，cTBS在治疗后立即显著降低食欲和戒断渴望。cTBS对戒断渴求的影响持续了24小时，并减少了吸烟。此外，cTBS显着加强rIFG的部分盖和胼胝体下扣带回之间（额-纹状体回路），rIFG的部分盖和右后海马旁回之间（额-边缘回路）的rsFC。在24 h后，cTBS诱导的额-纹状体rsFC增加与食欲渴求减少显著相关，而额-边缘系统rsFC增加与戒断渴求和吸烟减少显著相关。这些发现需要进一步研究rIFG cTBS在减弱ND患者吸烟行为方面的潜在价值。
Functional and anatomical irregularities in the right inferior frontal gyrus (rIFG), a ventrolateral prefrontal region that mediates top-down inhibitory control over prepotent behavioral responding, are implicated in the ongoing maintenance of nicotine dependence (ND). However, there is little research on the effects of neuromodulation of the rIFG on smoking behavior, inhibitory control, and resting-state functional connectivity (rsFC) among individuals with ND. In this double-blind, crossover, theta-burst stimulation (TBS) study, adults with ND (N = 31; female: n = 15) completed a baseline session and were then randomized to two counterbalanced sessions of functionally neuronavigated TBS to the rIFG: continuous TBS (cTBS) on 1 day and intermittent TBS (iTBS) on another. Differences in cigarette cravings, smoking, and fronto-striatal-limbic rsFC were assessed. Relative to baseline, cTBS significantly reduced appetitive and withdrawal cravings immediately after treatment. The effects of cTBS on withdrawal craving persisted for 24 h, as well as produced a reduction in smoking. Furthermore, cTBS significantly strengthened rsFC between the rIFG pars opercularis and subcallosal cingulate (fronto-striatal circuit), and between the rIFG pars opercularis and the right posterior parahippocampal gyrus (fronto-limbic circuit). At post-24 h, cTBS-induced increase in fronto-striatal rsFC was significantly associated with less appetitive craving, while the increase in fronto-limbic rsFC was significantly associated with less withdrawal craving and smoking. These findings warrant further investigation into the potential value of rIFG cTBS to attenuate smoking behavior among individuals with ND.
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影响因子：
4.2
作者：
Froeliger B;McConnell PA;Stankeviciute N;McClure EA;Kalivas PW;Gray KM
通讯作者：
Gray KM
影响因子：
4.7
作者：
Garland EL;Froeliger B;Howard MO
通讯作者：
Howard MO
影响因子：
25.8
作者：
Froeliger B;McConnell PA;Bell S;Sweitzer M;Kozink RV;Eichberg C;Hallyburton M;Kaiser N;Gray KM;McClernon FJ
通讯作者：
McClernon FJ
影响因子：
6
作者：
Amiaz, Revital;Levy, Dino;Zangen, Abraham
通讯作者：
Zangen, Abraham
影响因子：
34.7
作者：
Goldstein, Rita Z.;Volkow, Nora D.
通讯作者：
Volkow, Nora D.