Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications.
Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications.
复制标题
DOI：
10.1038/nrn3119
复制
发表时间：
2011-10-20
影响因子：
34.7
通讯作者：
Volkow, Nora D.
中科院分区：
文献类型：
--
作者：
Goldstein, Rita Z.;Volkow, Nora D.
成瘾时对药物摄入的失控最初被认为是皮层下奖赏回路中断的结果。然而，成瘾行为的成像研究已经确定了前额叶皮层（PFC）的关键参与，通过其调节边缘奖励区域和参与高阶执行功能（例如，自我控制，突出归因和意识）。这篇综述主要集中在过去十年中进行的功能性神经影像学研究，这些研究扩大了我们对PFC参与药物成瘾的理解。前额叶皮层在成瘾中的破坏不仅是强迫性吸毒的基础，而且也是与成瘾和自由意志侵蚀相关的不利行为的原因。
The loss of control over drug intake that occurs in addiction was initially believed to result from disruption of subcortical reward circuits. However, imaging studies in addictive behaviours have identified a key involvement of the prefrontal cortex (PFC) both through its regulation of limbic reward regions and its involvement in higher-order executive function (for example, self-control, salience attribution and awareness). This Review focuses on functional neuroimaging studies conducted in the past decade that have expanded our understanding of the involvement of the PFC in drug addiction. Disruption of the PFC in addiction underlies not only compulsive drug taking but also accounts for the disadvantageous behaviours that are associated with addiction and the erosion of free will.
登录
查看更多内容
影响因子：
4.2
作者：
Aharonovich, E;Hasin, DS;Nunes, EV
通讯作者：
Nunes, EV
影响因子：
7.6
作者：
Adinoff, Bryon;Devous, Michael D., Sr.;Cullum, Munro
通讯作者：
Cullum, Munro
影响因子：
7.6
作者：
Chanraud, Sandra;Martelli, Catherine;Martinot, Jean-Luc
通讯作者：
Martinot, Jean-Luc
影响因子：
--
作者：
Brody, AL;Mandelkern, MA;Jarvik, ME
通讯作者：
Jarvik, ME
影响因子：
16.2
作者：
Breiter, HC;Aharon, I;Shizgal, P
通讯作者：
Shizgal, P