Immunotherapies and immunomodulatory approaches in clinical trials - a mini review.
Immunotherapies and immunomodulatory approaches in clinical trials - a mini review.
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DOI：
10.1080/21645515.2020.1871295
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发表时间：
2021-07-03
影响因子：
4.8
通讯作者：
Dhama K
中科院分区：
文献类型：
--
作者：
Iqbal Yatoo M;Hamid Z;Rather I;Nazir QUA;Bhat RA;Ul Haq A;Magray SN;Haq Z;Sah R;Tiwari R;Natesan S;Bilal M;Harapan H;Dhama K
由严重急性呼吸道综合征冠状病毒2型（SARS-CoV-2）引起的冠状病毒病（COVID-19）大流行在全球范围内造成了严重破坏。由于没有任何针对COVID-19的疫苗或药物，涉及恢复期血浆、免疫球蛋白、抗体（单克隆或多克隆）的免疫疗法以及使用免疫调节剂增强免疫力是有价值的替代选择。基于细胞的疗法，包括自然杀伤细胞、T细胞、干细胞沿着细胞因子和基于Toll样受体（TLR）的疗法，也被潜在地用于对抗COVID-19。未来的研究需要加强开发有效的免疫治疗药物和免疫调节剂的领域，以提供适当、负担得起、方便和具有成本效益的预防和治疗方案，以应对全球COVID-19危机，这场危机导致世界各国进入医疗紧急状态，迫使其投入研究基础设施和人力来应对这一大流行病。
The coronavirus disease (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has created havoc worldwide. Due to the non-availability of any vaccine or drugs against COVID-19, immunotherapies involving convalescent plasma, immunoglobulins, antibodies (monoclonal or polyclonal), and the use of immunomodulatory agents to enhance immunity are valuable alternative options. Cell-based therapies including natural killer cells, T cells, stem cells along with cytokines and toll-like receptors (TLRs) based therapies are also being exploited potentially against COVID-19. Future research need to strengthen the field of developing effective immunotherapeutics and immunomodulators with a thrust of providing appropriate, affordable, convenient, and cost-effective prophylactic and treatment regimens to combat global COVID-19 crisis that has led to a state of medical emergency enforcing entire countries of the world to devote their research infrastructure and manpower in tackling this pandemic.
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DOI：
10.15557/pimr.2020.0003
发表时间：
2020-01-01
影响因子：
3.6
作者：
通讯作者：
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DOI：
10.1007/s10096-004-1271-9
发表时间：
2005-01
期刊：
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
影响因子：
--
作者：
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通讯作者：
Cheng G
影响因子：
8.3
作者：
Angelopoulou, Athina;Alexandris, Nikos;Poulas, Konstantinos
通讯作者：
Poulas, Konstantinos
影响因子：
4.7
作者：
Carballido, Estrella;Fishman, Mayer
通讯作者：
Fishman, Mayer
影响因子：
5.9
作者：
Chen, Liang;Hu, Chun;Du, Jun
通讯作者：
Du, Jun