Differential healing and neovascularization of ePTFE implants in subcutaneous versus adipose tissue.
Differential healing and neovascularization of ePTFE implants in subcutaneous versus adipose tissue.
复制标题
皮下组织与脂肪组织中 ePTFE 植入物的差异愈合和新生血管形成。
DOI：
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发表时间：
1997
期刊：
影响因子：
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通讯作者：
L. B. Kleinert
中科院分区：
文献类型：
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作者：
S. Williams;S. Berman;L. B. Kleinert
The preclinical evaluation of polymer biocompatibility is often performed using animal subcutaneous implant models. The choice of subcutaneous tissue as the implant site is due to a number of factors including simplicity of the surgery involved. Results from subcutaneous implants cannot necessarily be extrapolated to other tissues due to the differences in cellular composition of tissues. We have evaluated and compared the healing characteristics of expanded polytetrafluoroethylene (ePTFE) discs implanted in either subcutaneous tissue or epididymal fat pad tissue in rats. Following 3 and 5 weeks of implantation, the healing characteristics of discs were evaluated histologically with particular emphasis on tissue and polymer neovascularization. Implants placed in subcutaneous tissue exhibited limited formation of new microvascular elements within and directly in contact with the polymer, and the formation of an extensive fibrous capsule. In contrast, ePTFE implanted in the epididymal fat pads of rats exhibited extensive neovascularization of tissue surrounding the polymer, penetration of these microvascular cells into the graft interstices for distances < or = 100 microns and no morphological evidence of a fibrous capsule. The rat epididymal fat pad provides an alternative tissue for polymer healing evaluations. Due to the extensive presence of fat in subcutaneous tissue in humans, we suggest the fat pad model provides a more relevant preclinical evaluation of the healing characteristics of polymers used clinically in anatomic positions which contain significant amounts of fat.
预处理多孔网对体内基质纤维增生的影响。
DOI：
10.1002/jbm.820280209
发表时间：
1994
期刊：
Journal of biomedical materials research
影响因子：
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作者：
Trinkaus-Randall,V;Banwatt,R;Wu,XY;Leibowitz,HM;Franzblau,C
通讯作者：
Franzblau,C
血管移植物上内皮细胞的活体荧光显微镜检查。
DOI：
10.1016/0022-4804(89)90039-5
发表时间：
1989
期刊：
The Journal of surgical research
影响因子：
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作者：
Mechem,C;Jarrell,BE;Koolpe,E;Williams,SK
通讯作者：
Williams,SK