Regional white matter damage predicts speech fluency in chronic post-stroke aphasia.
Regional white matter damage predicts speech fluency in chronic post-stroke aphasia.
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DOI：
10.3389/fnhum.2014.00845
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发表时间：
2014
影响因子：
2.9
通讯作者：
Fridriksson J
中科院分区：
文献类型：
--
作者：
Basilakos A;Fillmore PT;Rorden C;Guo D;Bonilha L;Fridriksson J
最近，两个不同的白色物质区域，支持语言流畅性已被确定：斜束和前段的弓状束（ASAF）。ASAF的作用在卒中后失语患者中得到证实，而倾斜束的作用在原发性进行性失语中得到证实。区域白色物质的完整性似乎是至关重要的言语生产，然而，每个区域施加独立的影响言语流利的程度还不清楚。此外，目前还没有确定是否两个白色区域的损害影响语言的背景下，相同的神经机制（中风引起的失语症）。本研究评估了言语流利性和倾斜区域的定量完整性与ASAF之间的关系。它还探讨了语言流畅性和其他白色物质区域之间的关系，这些区域是典型的皮质语言区，如钩束和下纵束（ILF）。除了ILF，这些区域的损伤与语言流畅性相关，表明这些区域与卒中后失语的语言流畅性有协同关系。这些观察结果支持了这样一种理论，即语言流畅性需要运动前区、二级和三级联合皮层网络之间复杂的、协调的活动，而这些网络又受到区域白色物质完整性的支持。
Recently, two different white matter regions that support speech fluency have been identified: the aslant tract and the anterior segment of the arcuate fasciculus (ASAF). The role of the ASAF was demonstrated in patients with post-stroke aphasia, while the role of the aslant tract shown in primary progressive aphasia. Regional white matter integrity appears to be crucial for speech production; however, the degree that each region exerts an independent influence on speech fluency is unclear. Furthermore, it is not yet defined if damage to both white matter regions influences speech in the context of the same neural mechanism (stroke-induced aphasia). This study assessed the relationship between speech fluency and quantitative integrity of the aslant region and the ASAF. It also explored the relationship between speech fluency and other white matter regions underlying classic cortical language areas such as the uncinate fasciculus and the inferior longitudinal fasciculus (ILF). Damage to these regions, except the ILF, was associated with speech fluency, suggesting synergistic association of these regions with speech fluency in post-stroke aphasia. These observations support the theory that speech fluency requires the complex, orchestrated activity between a network of pre-motor, secondary, and tertiary associative cortices, supported in turn by regional white matter integrity.
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