Early life stress and psychiatric disorder modulate cortical responses to affective stimuli.

Early life stress and psychiatric disorder modulate cortical responses to affective stimuli.
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早期生活压力和精神疾病调节皮质对情感刺激的反应

DOI:
10.1111/j.1469-8986.2009.00871.x
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发表时间:
2009
期刊:
影响因子:
3.7
通讯作者:
Rockstroh
Rockstroh
中科院分区:
心理学3区
文献类型:
--
作者:
Miller;Schupp;Borgelt;Awiszus;Elbert;Rockstroh

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改变的情感处理被认为是早期生活压力(ELS)和随后的精神病理学之间的中介。本研究旨在探讨ELS对精神病患者和健康人情感皮层加工的影响是否存在差异。在青春期开始前的压力经验的数量进行了评估,在50例诊断为重度抑郁症,精神分裂症,药物成瘾,或边缘性人格障碍和20名健康对照组。受试者监测愉快的,中性的,不愉快的图片在脑磁图记录。刺激开始后160-210 ms的右后活动抑制与某些诊断和高ELS相关。结果证实了ELS与成人应激、共病创伤后应激障碍或抑郁症的具体贡献。
Altered affective processing has been proposed as mediating between early life stress (ELS) and subsequent psychopathology. The present study examined whether ELS influences affective cortical processing differently in psychiatric patients and healthy subjects. The number of stressful experiences before onset of puberty was assessed in 50 inpatients with diagnoses of Major Depressive Disorder, schizophrenia, drug addiction, or Borderline Personality Disorder and in 20 healthy comparison subjects. Subjects monitored pleasant, neutral, and unpleasant pictures during magnetoencephalographic recording. Suppression of right‐posterior activity 160–210 ms after stimulus onset was associated with certain diagnoses and high ELS. Results confirmed specific contributions of ELS versus adult stress, comorbid posttraumatic stress disorder, or depression.
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发表时间: 2000-06-01
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