Cognitive function in peripheral autonomic disorders.
Cognitive function in peripheral autonomic disorders.
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DOI：
10.1371/journal.pone.0085020
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Cortelli P
中科院分区：
文献类型：
--
作者：
Guaraldi P;Poda R;Calandra-Buonaura G;Solieri L;Sambati L;Gallassi R;Cortelli P
本研究的目的是：1）评价外周源性自主神经功能衰竭（AF）患者的整体认知功能; 2）研究符合直立性低血压（OH）标准的血压（BP）下降对认知功能的影响。我们评估了12例连续的单纯房颤（PAF）或自身免疫性自主神经病变（AAN）患者（10例男性，68±7岁）和12例年龄和性别匹配的对照组。所有患者均无中枢神经系统受累的临床体征，脑部CT/MRI扫描正常。在3种条件下连续两天评估认知功能：第1天，坐着时，通过一系列综合神经心理学测试;第2天，以随机方式倾斜（HUT）和仰卧休息（仰卧）。血压和心率（HR）在整个检查过程中连续无创记录。PAF或AAN患者在坐位时显示出保留的整体认知功能。然而，与仰卧位评估相比，在HUT期间，患者在连线测试A和B、弹幕测试、类比测试、即时视觉记忆、向前跨度和向后跨度测试中得分显著更差。病理评分，关于意大利的正常范围值，观察到只有在HUT中的障碍测试和类比测试分别在3和6例患者。相反，在健康对照组中，与仰卧休息相比，HUT期间的神经心理学测试结果没有显著差异。这些数据表明PAF和AAN患者表现出正常的坐姿整体认知评估。然而，他们的执行功能在立位挑战期间显著恶化，可能是因为短暂的额叶灌注不足。
aims of the current study were 1) to evaluate global cognitive function in patients with autonomic failure (AF) of peripheral origin and 2) to investigate the effect of a documented fall in blood pressure (BP) fulfilling the criteria for orthostatic hypotension (OH) on cognitive performances. we assessed 12 consecutive patients (10 males, 68±7 years old) with pure AF (PAF) or autoimmune autonomic neuropathy (AAN) and 12 age- and gender-matched controls. All patients had no clinical signs of central nervous system involvement and normal brain CT/MRI scan. Cognitive function was assessed on two consecutive days in 3 conditions: on day 1, while sitting, by means of a comprehensive battery of neuropsychological tests; on day 2, while tilted (HUT) and during supine rest (supine) in a randomized manner. BP and heart rate (HR) were continuously recorded non-invasively for the whole duration of the examination. patients with PAF or AAN displayed a preserved global cognitive function while sitting. However, compared to supine assessment, during HUT patients scored significantly worse during the Trail Making Test A and B, Barrage test, Analogies test, Immediate Visual Memory, Span Forward and Span Backward test. Pathological scores, with regard to Italian normative range values, were observed only during HUT in the Barrage test and in the Analogies test in 3 and 6 patients respectively. On the contrary, in healthy controls, results to neuropsychological tests were not significantly different, during HUT compared to supine rest. these data demonstrate that patients with PAF and AAN present a normal sitting global cognitive evaluation. However, their executive functions worsen significantly during the orthostatic challenge, possibly because of transient frontal lobes hypoperfusion.
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影响因子：
5.8
作者：
Heims, HC;Critchley, HD;Cipolotti, L
通讯作者：
Cipolotti, L
影响因子：
5.7
作者：
Rose, Kathryn M.;Couper, David;Gottesman, Rebecca F.
通讯作者：
Gottesman, Rebecca F.
DOI：
10.1007/bf01997792
发表时间：
1996-08-01
期刊：
ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES
影响因子：
--
作者：
Giovagnoli, AR;DelPesce, M;Capitani, E
通讯作者：
Capitani, E
影响因子：
6.7
作者：
GALLASSI, R;LENZI, P;MUSSUTO, V
通讯作者：
MUSSUTO, V
影响因子：
3.3
作者：
Gallassi, Roberto;Oppi, Federico;Sambati, Luisa
通讯作者：
Sambati, Luisa