Complete Nucleotide Sequence of a Novel Plasmid Bearing the High-Level Tigecycline Resistance Gene tet(X4)
Complete Nucleotide Sequence of a Novel Plasmid Bearing the High-Level Tigecycline Resistance Gene tet(X4)
复制标题
带有高水平替加环素抗性基因tet(X4)的新型质粒的完整核苷酸序列
DOI：
10.1128/aac.01373-19
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发表时间：
2019-09
影响因子：
4.9
通讯作者：
Sun Jian
中科院分区：
文献类型：
--
作者：
Fang Liang Xing;Chen Chong;Yu Dong Ling;Sun Ruan Yang;Cui Chao Yue;Chen Liang;Liao Xiao Ping;Liu Ya Hong;Sun Jian
我们报道了从中国分离的耐替加氯青霉素的大肠杆菌中分离的携带泰特（X4）质粒pSTB 20 - 1 T的全核苷酸序列。序列分析表明，pSTB 20 - 1 T含有一个杂合质粒骨架和一个含泰特（X4）的多药耐药区，可能来源于多个质粒的重组。泰特（X4）的侧翼是两个ISCR 2，这可能是泰特（X4）动员的原因。摘要我们报道了从中国分离的耐替加氯青霉素大肠杆菌中分离的携带泰特（X4）质粒pSTB 20 - 1 T的全核苷酸序列。序列分析表明，pSTB 20 - 1 T含有一个杂合质粒骨架和一个含泰特（X4）的多药耐药区，可能来源于多个质粒的重组。泰特（X4）的侧翼是两个ISCR 2，这可能是泰特（X4）动员的原因。这种新的杂交质粒的出现和传播可能会加剧具有临床意义的泰特（X4）基因的传播。
We reported the complete nucleotide sequence of a tet(X4)-carrying plasmid, pSTB20-1T, from a tigecycline-resistant Escherichia coli isolate in China. Sequence analysis indicated that pSTB20-1T contains a hybrid plasmid backbone and a tet(X4)-containing multidrug resistance region, likely originated through recombination of multiple plasmids. tet(X4) was flanked by two ISCR2, which may be responsible for tet(X4) mobilization. ABSTRACT We reported the complete nucleotide sequence of a tet(X4)-carrying plasmid, pSTB20-1T, from a tigecycline-resistant Escherichia coli isolate in China. Sequence analysis indicated that pSTB20-1T contains a hybrid plasmid backbone and a tet(X4)-containing multidrug resistance region, likely originated through recombination of multiple plasmids. tet(X4) was flanked by two ISCR2, which may be responsible for tet(X4) mobilization. The occurrence and transmission of this novel hybrid plasmid may exacerbate the spread of the clinically significant tet(X4) gene.
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影响因子：
4.9
作者：
Xiu-Mei Wang;Zhimin Dong;S. Schwarz;Yao Zhu;Xin Hua;Yanhe Zhang;Siguo Liu;Wanjiang Zhang
通讯作者：
Xiu-Mei Wang;Zhimin Dong;S. Schwarz;Yao Zhu;Xin Hua;Yanhe Zhang;Siguo Liu;Wanjiang Zhang
影响因子：
3.7
作者：
Walker BJ;Abeel T;Shea T;Priest M;Abouelliel A;Sakthikumar S;Cuomo CA;Zeng Q;Wortman J;Young SK;Earl AM
通讯作者：
Earl AM
影响因子：
4.3
作者：
R. Wick;L. Judd;C. Gorrie;K. Holt
通讯作者：
R. Wick;L. Judd;C. Gorrie;K. Holt
影响因子：
4.3
作者：
Wick, Ryan R.;Judd, Louise M.;Holt, Kathryn E.
通讯作者：
Holt, Kathryn E.
影响因子：
4.4
作者：
Aziz RK;Bartels D;Best AA;DeJongh M;Disz T;Edwards RA;Formsma K;Gerdes S;Glass EM;Kubal M;Meyer F;Olsen GJ;Olson R;Osterman AL;Overbeek RA;McNeil LK;Paarmann D;Paczian T;Parrello B;Pusch GD;Reich C;Stevens R;Vassieva O;Vonstein V;Wilke A;Zagnitko O
通讯作者：
Zagnitko O