The role of microRNAs in nasopharyngeal carcinoma.

The role of microRNAs in nasopharyngeal carcinoma.
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microRNA在鼻咽癌中的作用

DOI:
10.1007/s13277-014-2847-3
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发表时间:
2015-01
期刊:
影响因子:
--
通讯作者:
Tang, Faqing
Tang, Faqing
中科院分区:
其他
文献类型:
--
作者:
Tan, Gongjun;Tang, Xiaowei;Tang, Faqing

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鼻咽癌(NPC)是一种独特的头颈部癌症,在东南亚和中国南部很流行。民族背景和环境因素有助于NPC的发展,使其发病机制更加复杂。越来越多的证据表明microRNAs(miRNAs)在鼻咽癌的发生发展中起着重要作用,其中32种miRNAs参与了鼻咽癌的发生、发展和转移。miRNA在NPC中的因果关系及其作为生物标志物的可能用途已被广泛研究,结果令人鼓舞,证明了miRNA在NPC中的诊断和治疗潜力。本文就目前已知的参与鼻咽癌信号通路的miRNAs进行综述。
Nasopharyngeal carcinoma (NPC), a distinct type of head and neck cancer, is prevalent in Southeast Asia and southern China. Ethnic background and environmental factors contribute to the development of NPC, further complicating its pathogenesis. An increasing body of evidence indicates that microRNAs (miRNAs) play an important role in the development and progression of NPC, in particular, 32 miRNAs are involved in NPC tumorigenesis, progression, and metastasis. The causal involvement of miRNAs in NPC and their possible use as biomarkers have been extensively studied with promising results, demonstrating the diagnostic and therapeutic potential of miRNAs in NPC. In this review, we summarize the role of all the known miRNAs involved in the signaling pathway implicated in NPC.
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