Role of Innate Immune System in Environmental Lung Diseases.
Role of Innate Immune System in Environmental Lung Diseases.
复制标题
先天免疫系统在环境性肺部疾病中的作用。
DOI：
10.1007/s11882-021-01011-0
复制
发表时间：
2021-05-10
影响因子：
5.5
通讯作者：
Tighe RM
中科院分区：
文献类型：
--
作者：
Guttenberg MA;Vose AT;Tighe RM
肺粘膜作为身体与吸入的环境刺激物和病原体之间的主要屏障发挥作用。在这个肺环境界面需要精确和有针对性的监测机制，以维持体内平衡和保护气体交换。这是由先天免疫系统执行的，这是一种种系编码的系统，调节对外来刺激物和病原体的初始反应。环境污染物，如颗粒物（PM）、臭氧（O3）和其他燃烧产物（NO2、SO3等）两者都刺激和破坏肺的先天免疫系统的功能，导致潜在的病理后果。这篇综述的目的是探讨最近的发现和调查的先天免疫系统在应对环境暴露的作用。这集中于先天免疫系统的正常功能被环境因子改变从而导致呼吸功能中断的机制。这是一个叙述性的审查机制，肺先天免疫和环境暴露对这些反应的影响。本综述中强调的最新研究结果按先天免疫的特定组分进行分类，包括上皮功能，巨噬细胞，模式识别受体和微生物组。总体而言，该综述支持环境暴露对正常先天免疫功能改变的广泛影响，并对肺部疾病的发病率和恶化具有重要意义。先天免疫系统在维持肺部动态平衡以应对吸入的空气污染物方面发挥着关键作用。由于这些药物中有许多无法缓解，因此了解其机制影响对于开发未来干预措施以限制其病理后果至关重要。
The lung mucosa functions as a principal barrier between the body and inhaled environmental irritants and pathogens. Precise and targeted surveillance mechanisms are required at this lung-environment interface to maintain homeostasis and preserve gas exchange. This is performed by the innate immune system, a germline-encoded system that regulates initial responses to foreign irritants and pathogens. Environmental pollutants, such as particulate matter (PM), Ozone (O3), and other products of combustion (NO2, SO3, etc.) both stimulate and disrupt the function of the innate immune system of the lung, leading to the potential for pathologic consequences. The purpose of this review is to explore recent discoveries and investigations into the role of the innate immune system in responding to environmental exposures. This focuses on mechanisms by which the normal function of the innate immune system is modified by environmental agents leading to disruptions in respiratory function. This is a narrative review of mechanisms of pulmonary innate immunity and the impact of environmental exposures on these responses. Recent findings highlighted in this review are categorized by specific components of innate immunity including epithelial function, macrophages, pattern recognition receptors, and the microbiome. Overall, the review supports broad impacts of environmental exposures to alterations to normal innate immune functions and have important implications for incidence and exacerbations of lung disease. The innate immune system plays a critical role in maintaining pulmonary homeostasis in response to inhaled air pollutants. As many of these agents are unable to be mitigated, understanding their mechanistic impact is critical to develop future interventions to limit their pathologic consequences.
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DOI：
10.1165/rcmb.2018-0099oc
发表时间：
2019-02-01
影响因子：
6.4
作者：
Cho, Youngji;Abu-Ali, Galeb;Shore, Stephanie A.
通讯作者：
Shore, Stephanie A.
DOI：
10.1183/16000617.0066-2019
发表时间：
2019-09-30
期刊：
European respiratory review : an official journal of the European Respiratory Society
影响因子：
--
作者：
通讯作者：
--
影响因子：
9.1
作者：
Chatkin J;Correa L;Santos U
通讯作者：
Santos U
城市颗粒物 (PM) 抑制气道抗菌防御
影响因子：
5.8
作者：
Chen X;Liu J;Zhou J;Wang J;Chen C;Song Y;Pan J
通讯作者：
Pan J
影响因子：
3.8
作者：
BECKER, S;MADDEN, MC;KOREN, HS
通讯作者：
KOREN, HS