The effects of propofol on local field potential spectra, action potential firing rate, and their temporal relationship in humans and felines.
The effects of propofol on local field potential spectra, action potential firing rate, and their temporal relationship in humans and felines.
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DOI：
10.3389/fnhum.2013.00136
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发表时间：
2013
影响因子：
2.9
通讯作者：
House PA
中科院分区：
文献类型：
--
作者：
Hanrahan SJ;Greger B;Parker RA;Ogura T;Obara S;Egan TD;House PA
异丙酚是一种静脉镇静催眠药，作为GABAA激动剂，导致新皮质抑制。虽然异丙酚已经在分子和临床水平上得到了很好的研究，但关于异丙酚在单个神经元和局部新皮质网络水平上的作用却知之甚少。采用犹他州电极阵列(UEA)研究异丙酚麻醉对动作电位(AP)和局部场电位(LFP)的影响。在两名人类和三只猫科动物的大脑皮层内植入了尿激素A。两名人类患者和一只猫接受了丙泊酚团注，而另外两只猫接受了靶控输液。我们检测了不同麻醉水平下LFP功率谱和AP放电的变化。异丙酚浓度的增加与LFP频谱高频功率的降低、AP放电频率的降低以及大幅值棘状LFP活动的产生相关；然而，AP和LFP之间的时间关系在所有异丙酚水平下保持相对一致。使用异丙酚后，AP在局部最低LFP时开火的概率增加。异丙酚对新皮质网络活动的抑制使LFP以低频率的棘波活动为主，并与镇静和意识丧失相关。随着低频棘波活动的增加，AP-LFP关系变得更具可预测性，放电频率编码能力受损。这表明了新大脑皮层信息处理减少的机制，这是异丙酚诱导的意识丧失的原因。
Propofol is an intravenous sedative hypnotic, which, acting as a GABAA agonist, results in neocortical inhibition. While propofol has been well studied at the molecular and clinical level, less is known about the effects of propofol at the level of individual neurons and local neocortical networks. We used Utah Electrode Arrays (UEAs) to investigate the effects of propofol anesthesia on action potentials (APs) and local field potentials (LFPs). UEAs were implanted into the neocortex of two humans and three felines. The two human patients and one feline received propofol by bolus injection, while the other two felines received target-controlled infusions. We examined the changes in LFP power spectra and AP firing at different levels of anesthesia. Increased propofol concentration correlated with decreased high-frequency power in LFP spectra and decreased AP firing rates, and the generation of large-amplitude spike-like LFP activity; however, the temporal relationship between APs and LFPs remained relatively consistent at all levels of propofol. The probability that an AP would fire at this local minimum of the LFP increased with propofol administration. The propofol-induced suppression of neocortical network activity allowed LFPs to be dominated by low-frequency spike-like activity, and correlated with sedation and unconsciousness. As the low-frequency spike-like activity increased and the AP–LFP relationship became more predictable firing rate encoding capacity is impaired. This suggests a mechanism for decreased information processing in the neocortex that accounts for propofol-induced unconsciousness.
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影响因子：
5.3
作者：
Bai, DL;Pennefather, PS;Orser, BA
通讯作者：
Orser, BA
DOI：
10.1056/nejmra0808281
发表时间：
2010-12-30
期刊：
The New England journal of medicine
影响因子：
--
作者：
Brown EN;Lydic R;Schiff ND
通讯作者：
Schiff ND
细胞外田地和电流的起源-EEG，ECOG，LFP和尖峰。
DOI：
10.1038/nrn3241
发表时间：
2012-05-18
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Buzsáki G;Anastassiou CA;Koch C
通讯作者：
Koch C
影响因子：
3.4
作者：
Erchova, IA;Lebedev, MA;Diamond, ME
通讯作者：
Diamond, ME
影响因子：
5.3
作者：
Khawaja, Farhan A.;Tsui, James M. G.;Pack, Christopher C.
通讯作者：
Pack, Christopher C.