FDG-PET/CT imaging parameters for predicting spontaneous regression of methotrexate-associated lymphoproliferative disorder in patients with rheumatoid arthritis.
FDG-PET/CT imaging parameters for predicting spontaneous regression of methotrexate-associated lymphoproliferative disorder in patients with rheumatoid arthritis.
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DOI：
10.1038/s41598-022-19727-y
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发表时间：
2022-09-13
影响因子：
4.6
通讯作者：
Dobashi, Hiroaki
中科院分区：
文献类型：
--
作者：
Kameda, Tomohiro;Nakashima, Shusaku;Mitamura, Katsuya;Yamamoto, Yuka;Norikane, Takashi;Shimada, Hiromi;Wakiya, Risa;Kato, Mikiya;Miyagi, Taichi;Sugihara, Koichi;Mino, Rina;Mizusaki, Mao;Kadowaki, Norimitsu;Dobashi, Hiroaki
在这项研究中，我们调查了FDG-PET/CT预测甲氨蝶呤相关淋巴细胞增生性疾病（MTX-LPD）自发消退的有效性。20名诊断为MTX-LPD的类风湿性关节炎患者参加了这项研究。这些患者分为自发性消退组（SR组：10例）和MTX停药后化疗组（CTx组：10例）。比较各组间潜在生物标志物的差异，包括LPD发病时的临床标志物[血清LDH和白细胞介素2受体（sIL-2R）]，随访期间外周血淋巴细胞绝对数量的变化（ΔALC），以及FDG-PET/ ct衍生的最大标准化摄取值（SUVmax）、平均SUV （SUVmean）、峰值SUV （SUVpeak）、代谢肿瘤体积总和（MTVsum）和病变总糖酵解总和（TLGsum）等参数。SR组sIL-2R、MTVsum、TLGsum水平明显低于CTx组。此外，SR组的ΔALC较高。综上所述，FDG-PET/CT测量的MTV和TLG值可能适合作为MTX-LPD患者SR的预测指标。
In this study, we investigated the usefulness of FDG-PET/CT for predicting spontaneous regression in methotrexate-associated lymphoproliferative disorder (MTX-LPD). Twenty patients with rheumatoid arthritis who were diagnosed with MTX-LPD were enrolled in the study. These patients were divided into those who showed spontaneous regression (SR group: ten patients) and those who received chemotherapy after discontinuation of MTX (CTx group: ten patients). Between-group differences in potential biomarkers were compared, including clinical markers at the onset of LPD [serum LDH and interleukin 2 receptor (sIL-2R)], change in absolute number of peripheral lymphocytes (ΔALC) over follow-up, and the FDG-PET/CT-derived parameters of maximum standardized uptake value (SUVmax), mean SUV (SUVmean), peak SUV (SUVpeak), sum of the metabolic tumor volume (MTVsum), and sum of total lesion glycolysis (TLGsum). The levels of sIL-2R, MTVsum, and TLGsum were significantly lower in the SR group than in the CTx group. In addition, ΔALC was higher in the SR group. In conclusion, MTV and TLG values measured by FDG-PET/CT may be suitable for use as predictors of SR in patients with MTX-LPD.
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