Genome editing of avian species: implications for animal use and welfare.

Genome editing of avian species: implications for animal use and welfare.
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DOI:
10.1177/0023677221998400
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发表时间:
2022-03
期刊:
影响因子:
2.4
通讯作者:
McGrew MJ
McGrew MJ
中科院分区:
医学4区
文献类型:
--
作者:
Panda SK;McGrew MJ

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鸟类物种被用作研究的模型系统,并为发育生物学、免疫学、遗传学、病毒学、癌症和细胞生物学领域的突破性概念做出了贡献。尤其是鸡,它是一种重要的研究模型,也是一种农业动物,是全球人口动物蛋白资源的主要贡献者。开发基因组编辑方法(包括 CRISPR/Cas9)来介导鸟类基因组种系工程,将在生物医学、农业和生物技术活动中具有重要应用。值得注意的是,这些精确的基因组编辑工具有可能通过识别和验证鸟类种群中有益的遗传变异来增强鸟类的健康和生产力。在这里,我们简要描述了鸟类基因组编辑工具的现有方法和当前应用,重点是鸡,并关注所提出的每种技术的动物使用和福利问题。
Avian species are used as model systems in research and have contributed to ground-breaking concepts in developmental biology, immunology, genetics, virology, cancer and cell biology. The chicken in particular is an important research model and an agricultural animal as a major contributor to animal protein resources for the global population. The development of genome editing methods, including CRISPR/Cas9, to mediate germline engineering of the avian genome will have important applications in biomedical, agricultural and biotechnological activities. Notably, these precise genome editing tools have the potential to enhance avian health and productivity by identifying and validating beneficial genetic variants in bird populations. Here, we present a concise description of the existing methods and current applications of the genome editing tools in bird species, focused on chickens, with attention on animal use and welfare issues for each of the techniques presented.
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