Lectin Protein as a Promising Component to Functionalize Micelles, Liposomes and Lipid NPs against Coronavirus.

Lectin Protein as a Promising Component to Functionalize Micelles, Liposomes and Lipid NPs against Coronavirus.
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DOI:
10.3390/biomedicines8120580
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发表时间:
2020-12-07
期刊:
影响因子:
4.7
通讯作者:
Nokhodchi A
Nokhodchi A
中科院分区:
工程技术3区
文献类型:
--
作者:
Alavi M;Asare-Addo K;Nokhodchi A

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2019年12月,一种新型冠状病毒株作为COVID-19肺炎的病原体,首次在中国武汉被发现,引发了对冠状病毒毒力能力的高度关注。凝集素是一种天然蛋白质,具有结合与各种微生物有关的特定碳水化合物的能力,包括病毒、细菌、真菌和寄生虫。凝集素具有凝集和中和这些致病机制的能力。通过功能化胶束和脂质体制剂,可以将包封的抗病毒药物或疫苗跨细胞膜递送。在这篇综述中,介绍了具有抑制冠状病毒活性的重要凝集素的最新进展和挑战,以获得胶束和脂质体细胞结合载体微制剂或纳米制剂的新观点。
The outbreak of a novel strain coronavirus as the causative agent of COVID-19 pneumonia, first identified in Wuhan, China in December 2019, has resulted in considerable focus on virulence abilities of coronavirus. Lectins are natural proteins with the ability to bind specific carbohydrates related to various microorganisms, including viruses, bacteria, fungi and parasites. Lectins have the ability to agglutinate and neutralize these pathogeneses. The delivery of the encapsulated antiviral agents or vaccines across the cell membrane can be possible by functionalized micellar and liposomal formulations. In this mini-review, recent advances and challenges related to important lectins with inhibition activities against coronaviruses are presented to obtain a novel viewpoint of microformulations or nanoformulations by micellar and liposomal cell-binding carriers.
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