HEMODYNAMIC ANALYSIS OF CAROTID SIPHON WITH UNILATERAL STENOSIS: SIGNIFICANCE OF ARTERIAL GEOMETRY
HEMODYNAMIC ANALYSIS OF CAROTID SIPHON WITH UNILATERAL STENOSIS: SIGNIFICANCE OF ARTERIAL GEOMETRY
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单侧狭窄颈动脉虹吸管的血流动力学分析：动脉几何形状的意义
DOI：
10.4015/s1016237214500653
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发表时间：
2014-12
期刊：
影响因子：
--
通讯作者：
Deyu Li
中科院分区：
文献类型：
--
作者：
Shuyu Li;Fang Pu;Yubo Fan;Deyu Li
动脉的几何形状影响局部的血流动力学，被认为是动脉粥样硬化的重要危险因素。但动脉形状对颈内动脉狭窄的影响尚不清楚。研究了4名被诊断为单侧狭窄的两种几何形状不同的ICA受试者，以澄清伊卡形状与狭窄之间的关联。采集受试者伊卡两支的磁共振血管造影（MRA）图像，并重建成3D模型。去除ICA的分叉和锥度。计算模拟模型中的脉动流，以评估动脉几何形状对血液动力学的影响。由于ICA的两个分支之间的不同几何形状，血流动力学模式明显不同。左伊卡分支的壁面剪切应力梯度（WSSG）和振荡剪切指数（OSI）较低，在那里发现螺旋流，因为弯曲的大的非平面性。动脉几何形状的差异可能是本研究中狭窄的唯一原因。此外，颈动脉虹吸管的平面性是两个分支之间唯一显著不同的几何因素。因此，平面性被认为是ICA狭窄的最重要的几何因素。
Geometry of arteries has been considered as an important risk factor for atherosclerosis, because it influences the local hemodynamics. But the effect of the arterial shape on the internal carotid arterial (ICA) stenosis remains unknown. Four subjects with two geometrically different ICAs, diagnosed with unilateral stenosis, were investigated to clarify the association between the ICA shape and the stenosis. Magnetic resonance angiography (MRA) images of the two branches of ICA were acquired from the subject, and reconstructed into 3D models. The bifurcations and taper of the ICAs were removed. The pulsatile flow in the models was computationally simulated to evaluate the effect of the arterial geometry on hemodynamics. Because of the different geometry between the two branches of ICAs, the hemodynamic pattern is obviously different. The wall shear stress gradient (WSSG) and oscillating shear index (OSI) is lower in the left ICA branches, where helical flow is found, because of the large nonplanarity of bends. The difference of the arterial geometry is probably the only reason for the stenosis in this study. Furthermore, the planarity of the carotid siphon is the only geometric factor that is significantly different between the two branches. Consequently, the planarity is considered as the most important geometric factor for stenosis in ICAs.
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DOI：
10.1145/280811.281026
发表时间：
1998-07
期刊：
Seminal graphics: pioneering efforts that shaped the field
影响因子：
--
作者：
W. Lorensen;H. Cline
通讯作者：
W. Lorensen;H. Cline
影响因子：
8.3
作者：
Lee, Sang-Wook;Antiga, Luca;Steinman, David A.
通讯作者：
Steinman, David A.
影响因子：
5.3
作者：
K. van der Heiden;B. Hierck;R. Krams;R. de Crom;Caroline Cheng;M. Baiker;M. Pourquié;F. E. Alkemade;M. DeRuiter;A. G. Gittenberger-de Groot;R. Poelmann
通讯作者：
K. van der Heiden;B. Hierck;R. Krams;R. de Crom;Caroline Cheng;M. Baiker;M. Pourquié;F. E. Alkemade;M. DeRuiter;A. G. Gittenberger-de Groot;R. Poelmann
DOI：
10.1073/pnas.83.7.2114
发表时间：
1986-04-01
影响因子：
11.1
作者：
DAVIES, PF;REMUZZI, A;GIMBRONE, MA
通讯作者：
GIMBRONE, MA
影响因子：
37.8
作者：
KILNER, PJ;YANG, GZ;LONGMORE, DB
通讯作者：
LONGMORE, DB