Axonal transport of adeno-associated viral vectors is serotype-dependent.
Axonal transport of adeno-associated viral vectors is serotype-dependent.
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We have previously shown that AAV2 undergoes anterograde axonal transport in rat and non-human primate brain. We screened other AAV serotypes for axonal transport and found that AAV6 is transported almost exclusively in a retrograde direction and, like AAV2, it is also neuron-specific in rat brain. Our findings show that axonal transport of AAV is serotype-dependent and this has implications for gene therapy of neurological diseases such as Huntington’s disease.
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影响因子：
4.8
作者：
Fitzsimons, HL;Bland, RJ;During, MJ
通讯作者：
During, MJ
影响因子：
56.9
作者：
Kaspar, BK;Lladó, J;Gage, FH
通讯作者：
Gage, FH
影响因子：
12.4
作者：
Ciesielska, Agnieszka;Mittermeyer, Gabriele;Bankiewicz, Krystof S.
通讯作者：
Bankiewicz, Krystof S.
影响因子：
12.4
作者：
Klein, Ronald L.;Dayton, Robert D.;Henning, Phillip P.
通讯作者：
Henning, Phillip P.
影响因子：
1.7
作者：
Daadi, MM;Pivirotto, P;Bankiewicz, KS
通讯作者：
Bankiewicz, KS