Beyond the thrombus: Platelet-inspired nanomedicine approaches in inflammation, immune response, and cancer.
Beyond the thrombus: Platelet-inspired nanomedicine approaches in inflammation, immune response, and cancer.
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超越血栓：炎症，免疫反应和癌症中的血小板激发纳米医学方法。
DOI：
10.1111/jth.15733
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发表时间：
2022-07
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影响因子：
--
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血小板的传统作用是形成用于生理（例如，止血）或病理性（例如，在血栓形成中）功能。参与这些功能的血小板中的细胞和亚细胞机制和信号传导已被广泛阐明，新的知识不断涌现，导致该领域用于管理出血或血栓形成事件的各种治疗发展。纳米医学是一个涉及设计具有独特生物相互作用表面修饰和有效载荷封装的纳米颗粒以用于疾病靶向药物递送的领域，已成为此类治疗开发的重要组成部分。除了在凝血中的传统作用外，血小板还通过直接的细胞相互作用以及分泌有助于疾病微环境的可溶性因子，在其他疾病（包括炎症，免疫反应和癌症）中发挥关键的机械作用。迄今为止，利用血小板的这些更广泛作用的纳米医学系统的发展受到限制。此外，近年来出现的另一个令人兴奋的研究领域是血小板衍生的细胞外囊泡（PEV），它可以直接和间接地影响生理和病理过程。这使得PEV成为血小板激发治疗设计的独特范例。本综述旨在提供血小板和PEV参与止血和血栓形成以外的机制见解，并讨论这些领域血小板激发治疗技术开发的最新技术水平，重点是未来的机会。
The traditional role of platelets is in the formation of blood clots for physiologic (e.g., in hemostasis) or pathologic (e.g., in thrombosis) functions. The cellular and subcellular mechanisms and signaling in platelets involved in these functions have been extensively elucidated and new knowledge continues to emerge, resulting in various therapeutic developments in this area for the management of hemorrhagic or thrombotic events. Nanomedicine, a field involving design of nanoparticles with unique biointeractive surface modifications and payload encapsulation for disease‐targeted drug delivery, has become an important component of such therapeutic development. Beyond their traditional role in blood clotting, platelets have been implicated to play crucial mechanistic roles in other diseases including inflammation, immune response, and cancer, via direct cellular interactions, as well as secretion of soluble factors that aid in the disease microenvironment. To date, the development of nanomedicine systems that leverage these broader roles of platelets has been limited. Additionally, another exciting area of research that has emerged in recent years is that of platelet‐derived extracellular vesicles (PEVs) that can directly and indirectly influence physiological and pathological processes. This makes PEVs a unique paradigm for platelet‐inspired therapeutic design. This review aims to provide mechanistic insight into the involvement of platelets and PEVs beyond hemostasis and thrombosis, and to discuss the current state of the art in the development of platelet‐inspired therapeutic technologies in these areas, with an emphasis on future opportunities.
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影响因子：
4.7
作者：
Braun A;Anders HJ;Gudermann T;Mammadova-Bach E
通讯作者：
Mammadova-Bach E
影响因子：
--
作者：
Chang YW;Hsieh PW;Chang YT;Lu MH;Huang TF;Chong KY;Liao HR;Cheng JC;Tseng CP
通讯作者：
Tseng CP
影响因子：
3.8
作者：
Bakogiannis, Constantinos;Sachse, Marco;Stellos, Konstantinos
通讯作者：
Stellos, Konstantinos
DOI：
10.4049/jimmunol.1200580
发表时间：
2012-07-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Chapman LM;Aggrey AA;Field DJ;Srivastava K;Ture S;Yui K;Topham DJ;Baldwin WM 3rd;Morrell CN
通讯作者：
Morrell CN
影响因子：
7.4
作者：
Blair P;Flaumenhaft R
通讯作者：
Flaumenhaft R