Salivary 8-hydroxyguanine as a lifestyle-related oxidative stress biomarker in workers
Salivary 8-hydroxyguanine as a lifestyle-related oxidative stress biomarker in workers
复制标题
唾液 8-羟基鸟嘌呤作为工人生活方式相关氧化应激生物标志物
DOI：
10.3164/jcbn.19-72
复制
发表时间：
2020
影响因子：
2.4
通讯作者：
K. Kawai
中科院分区：
文献类型：
--
作者：
S. Watanabe;Y. Kawasaki;K. Kawai
Oxidative stress is a risk factor for lifestyle-related diseases, such as cancer. Investigations of the factors that increase or decrease oxidative stress contribute to disease prevention. In the present study, we focused on the 8-hydroxyguanine (8-OHGua) in saliva, as a new oxidative stress biomarker. The relationship between lifestyles and salivary 8-OHGua levels in 541 Japanese subjects was analyzed. The salivary 8-OHGua levels were significantly elevated in older persons, as well as those who smoke, have hypertension, or excess visceral fat. By contrast, statistically significant lower levels of 8-OHGua were observed in persons who moderately exercised or recently drank green tea or coffee. The direct collection of saliva, without any special collecting device, was suitable for the 8-OHGua analysis. The present results suggest that oxidative stress can be measured in a non-invasive manner with easily collectable saliva, and the salivary 8-OHGua may be a useful biomarker for lifestyle-related disease prevention.
影响因子：
7.4
作者：
Mecocci, P;Fanó, G;Beal, MF
通讯作者：
Beal, MF
DOI：
10.1016/0027-5107(95)00251-0
发表时间：
1996-04-13
影响因子：
2.3
作者：
Fraga, CG;Motchnik, PA;Ames, BN
通讯作者：
Ames, BN
DOI：
10.1056/nejmsr1606602
发表时间：
2016-08-25
期刊：
The New England journal of medicine
影响因子：
--
作者：
Lauby-Secretan B;Scoccianti C;Loomis D;Grosse Y;Bianchini F;Straif K;International Agency for Research on Cancer Handbook Working Group
通讯作者：
International Agency for Research on Cancer Handbook Working Group