Prenatal and postnatal parental smoking and acute otitis media in early childhood.
Prenatal and postnatal parental smoking and acute otitis media in early childhood.
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DOI：
10.1111/j.1651-2227.2009.01506.x
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发表时间：
2010-01
期刊：
影响因子：
--
通讯作者：
Nafstad P
中科院分区：
文献类型：
--
作者：
Håberg SE;Bentdal YE;London SJ;Kvaerner KJ;Nystad W;Nafstad P
探讨儿童早期急性中耳炎与出生前和出生后吸烟暴露之间的关系。研究对象是挪威母亲和儿童研究中2000年至2005年出生的32,077名儿童，调查对象是18个月以下的吸烟暴露和急性中耳炎的问卷数据。使用多元回归模型获得调整后的急性中耳炎的相对危险度。急性中耳炎在暴露于父母吸烟的儿童中略多见。非暴露组0~6个月发病率为4.7%，出生前和产后均暴露组发病率为6.0%。在调整出生后暴露和协变量后，孕期暴露于母亲吸烟的0-6个月急性中耳炎的相对风险为1.34，95%可信区间：1.06-1.69。孕妇怀孕期间吸烟与12个月以下的急性中耳炎有关。与非暴露儿童相比，出生前和出生后暴露的儿童复发急性中耳炎的风险略有增加，相对风险为1.24，95%可信区间：1.01-1.52。即使在父母吸烟水平相对较低的队列中，母亲怀孕期间吸烟也与儿童早期急性中耳炎的风险增加有关。
To explore associations between acute otitis media in early childhood and prenatal and postnatal tobacco smoke exposure. Subjects were 32,077 children born 2000 – 2005 in the Norwegian Mother and Child Study with questionnaire data on tobacco smoke exposure and acute otitis media up to 18 months of age. Multivariate regression models were used to obtain adjusted relative risks for acute otitis media. Acute otitis media was slightly more common in children exposed to parental smoking. The incidence from 0–6 months was 4.7% in unexposed children, and 6.0% in children exposed both pre-and postnatally. After adjusting for postnatal exposure and covariates, the relative risk for acute otitis media 0–6 months when exposed to maternal smoking in pregnancy was 1.34, 95% confidence interval: 1.06–1.69. Maternal smoking in pregnancy was associated with acute otitis media up to 12 months of age. Compared to non-exposed children, there was a slightly increased risk of recurrent acute otitis media for children exposed both pre- and postnatally with a relative risk of 1.24, 95% confidence interval: 1.01–1.52,. Even in a cohort with relatively low exposure levels of parental smoking, maternal smoking in pregnancy was associated with an increased risk of acute otitis media in early childhood.
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影响因子：
5.2
作者：
Pattenden, Sam;Antova, Temenuga;Fletcher, Tony
通讯作者：
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影响因子：
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作者：
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DOI：
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