Shallow breathing: bacterial life at low O(2).

Shallow breathing: bacterial life at low O(2).
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DOI:
10.1038/nrmicro2970
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发表时间:
2013-03
期刊:
Nature reviews. Microbiology
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其他
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呼吸微生物之间对分子氧(O2)的竞争是激烈的,因为O2是一种有效的电子受体。这种竞争导致微氧环境的形成,微生物聚集在水生,陆生和宿主相关的社区。细菌可以利用高亲和力的末端氧化酶以低浓度,甚至纳摩尔浓度收获O2。在这里,我们报告的调查结果,寻找高亲和力的终端氧化酶基因测序细菌基因组和鸟枪宏基因组。结果表明,具有在微氧条件下呼吸潜力的细菌在遗传上是多样的,并且在自然界中广泛存在。我们通过强调与健康和疾病相关的宿主相关细菌中微需氧代谢的重要性来探索这些发现的意义。
Competition for molecular oxygen (O2) among respiratory microorganisms is intense because O2 is a potent electron acceptor. This competition leads to the formation of microoxic environments wherever microorganisms congregate in aquatic, terrestrial and host-associated communities. Bacteria can harvest O2 present at low, even nanomolar, concentrations using high-affinity terminal oxidases. Here, we report the results of surveys searching for high-affinity terminal oxidase genes in sequenced bacterial genomes and shotgun metagenomes. The results indicate that bacteria with the potential to respire under microoxic conditions are phylogenetically diverse and intriguingly widespread in nature. We explore the implications of these findings by highlighting the importance of microaerobic metabolism in host-associated bacteria related to health and disease.
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