Interferon production in rat type II pneumocytes and alveolar macrophages.
Interferon production in rat type II pneumocytes and alveolar macrophages.
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大鼠 II 型肺细胞和肺泡巨噬细胞中干扰素的产生。
DOI：
--
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发表时间：
1989
影响因子：
1.7
通讯作者：
V. Castranova
中科院分区：
文献类型：
--
作者：
N. Hahon;V. Castranova
在分离自大鼠（Sprague-Dawley）的II型肺细胞和肺泡巨噬细胞中测定流感病毒诱导的干扰素产生的时程和幅度。虽然干扰素生产的高峰是约20小时在两种肺泡细胞类型，它是超过三至四倍高的II型细胞比巨噬细胞。在病毒诱导多重性以及任一肺泡细胞类型的群体数量和干扰素产量之间注意到剂量-反应关系。由大鼠II型细胞和肺泡巨噬细胞产生的病毒诱导的细胞因子表现出干扰素的生理化学和生物学特性，并且对于II型肺细胞，标志着它们迄今为止未被认识到的产生干扰素的能力。这些大鼠干扰素对不同来源的细胞提供的最佳跨种属抗病毒保护，以同源种属百分比（100%）表示，如下：豚鼠50%，小鼠40%，人和猴均为0%。来自大鼠肺泡巨噬细胞或II型细胞的干扰素对α干扰素敏感的豚鼠细胞的异源抗病毒活性表明，这些细胞因子可能与α样干扰素种类更明显相关。在大鼠肺泡巨噬细胞和II型肺细胞中，流感病毒和仙台病毒的生长被阻止。本文的研究结果表明，II型细胞可能是肺泡干扰素的主要来源，用于激活抗病毒状态和调节肺完整性所需的肺泡细胞功能。
The time course and magnitude of interferon production induced by influenza virus were determined in type II pneumocytes and alveolar macrophages isolated from rats (Sprague-Dawley). Although the peak of interferon production was approximately 20 h in both alveolar cell types, it was more than three- to fourfold higher in type II cells than in macrophages. Dose-response relationships were noted between the virus multiplicity of induction as well as population numbers of either alveolar cell type and interferon yields. The viral-induced cytokines produced by rat type II cells and alveolar macrophages exhibit physiochemical and biological properties characteristic of interferons and, with respect to type II pneumocytes, mark their heretofore unrecognized capability to produce interferon. The best cross-species antiviral protection afforded by these rat interferons to cells of different origin, expressed as percentage of homologous species (100%), was as follows: guinea pig 50, mouse 40%, and both human and monkey 0%. The heterologous antiviral activity by interferons from either rat alveolar macrophages or type II cells on alpha interferon-sensitive guinea pig cells suggests that these cytokines may be more appreciably related to the alpha-like interferon species. The growth of influenza and Sendai viruses was precluded in both rat alveolar macrophages and type II pneumocytes. The findings herein suggest that type II cells may be a major source of alveolar interferon for activating the antiviral state and modulating alveolar cell functions requisite for lung integrity.
肺 II 型上皮细胞合成胶原蛋白。
DOI：
10.1164/arrd.1987.135.5.1118
发表时间：
1987
期刊：
The American review of respiratory disease
影响因子：
--
作者：
Crouch,EC;Moxley,MA;Longmore,W
通讯作者：
Longmore,W
大鼠成纤维细胞干扰素与人和小鼠α干扰素的生物学相似性。
DOI：
10.1099/0022-1317-66-9-1961
发表时间：
1985
期刊：
The Journal of general virology
影响因子：
--
作者：
Davis,CT;Rusckowski,M;Murasko,DM
通讯作者：
Murasko,DM
原代培养物中的颗粒性肺细胞分泌细胞外基质的几种主要成分。
影响因子：
2.9
作者：
Sage,H;Farin,FM;Striker,GE;Fisher,AB
通讯作者：
Fisher,AB