Emergence and spread of SARS-CoV-2 lineage B.1.620 with variant of concern-like mutations and deletions.
Emergence and spread of SARS-CoV-2 lineage B.1.620 with variant of concern-like mutations and deletions.
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DOI：
10.1038/s41467-021-26055-8
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发表时间：
2021-10-01
影响因子：
16.6
通讯作者：
Baele G
中科院分区：
文献类型：
--
作者：
Dudas G;Hong SL;Potter BI;Calvignac-Spencer S;Niatou-Singa FS;Tombolomako TB;Fuh-Neba T;Vickos U;Ulrich M;Leendertz FH;Khan K;Huber C;Watts A;Olendraitė I;Snijder J;Wijnant KN;Bonvin AMJJ;Martres P;Behillil S;Ayouba A;Maidadi MF;Djomsi DM;Godwe C;Butel C;Šimaitis A;Gabrielaitė M;Katėnaitė M;Norvilas R;Raugaitė L;Koyaweda GW;Kandou JK;Jonikas R;Nasvytienė I;Žemeckienė Ž;Gečys D;Tamušauskaitė K;Norkienė M;Vasiliūnaitė E;Žiogienė D;Timinskas A;Šukys M;Šarauskas M;Alzbutas G;Aziza AA;Lusamaki EK;Cigolo JM;Mawete FM;Lofiko EL;Kingebeni PM;Tamfum JM;Belizaire MRD;Essomba RG;Assoumou MCO;Mboringong AB;Dieng AB;Juozapaitė D;Hosch S;Obama J;Ayekaba MO;Naumovas D;Pautienius A;Rafaï CD;Vitkauskienė A;Ugenskienė R;Gedvilaitė A;Čereškevičius D;Lesauskaitė V;Žemaitis L;Griškevičius L;Baele G
通过各种基因组监测计划发现的独特的SARS-CoV-2谱系在全球人口流动性空前减少后的大流行期间出现。我们在这里描述了一个SARS-CoV-2谱系-命名为B.1.620 -在立陶宛发现，并携带许多突变和缺失的刺突蛋白共享的广泛关注的变体（VOC），包括E484 K，S477 N和缺失HV 69 Δ，Y144Δ，和LLA 241/243Δ。除了记录该谱系携带的突变套件外，我们还描述了其对中和抗体具有抗性的潜力，欧洲病例子集的旅行史，欧洲当地B.1.620传播的证据，重点是立陶宛，以及由于最近的基因组测序工作，其在中非流行的意义。我们使其可能的中非起源的情况下，使用先进的地理推断方法，将记录的旅行历史的受感染的旅客。在这里，作者描述了一种新的潜在SARS-CoV-2变异体B.1.620的出现和传播。他们表明，这种血统首先在立陶宛发现，已经在欧洲多次建立了地方传播，并可能出现在中非。
Distinct SARS-CoV-2 lineages, discovered through various genomic surveillance initiatives, have emerged during the pandemic following unprecedented reductions in worldwide human mobility. We here describe a SARS-CoV-2 lineage - designated B.1.620 - discovered in Lithuania and carrying many mutations and deletions in the spike protein shared with widespread variants of concern (VOCs), including E484K, S477N and deletions HV69Δ, Y144Δ, and LLA241/243Δ. As well as documenting the suite of mutations this lineage carries, we also describe its potential to be resistant to neutralising antibodies, accompanying travel histories for a subset of European cases, evidence of local B.1.620 transmission in Europe with a focus on Lithuania, and significance of its prevalence in Central Africa owing to recent genome sequencing efforts there. We make a case for its likely Central African origin using advanced phylogeographic inference methodologies incorporating recorded travel histories of infected travellers. Here, the authors describe the emergence and spread of a new potential SARS-CoV-2 variant of interest, B.1.620. They show that this lineage, first identified in Lithuania, has established local transmission in Europe on multiple occasions and likely emerged in Central Africa.
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DOI：
10.1002/cjs.5550360302
发表时间：
2008-09-01
影响因子：
0.6
作者：
Ferreira, Marco A. R.;Suchard, Marc A.
通讯作者：
Suchard, Marc A.
影响因子：
6.5
作者：
Baele, Guy;Lemey, Philippe;Suchard, Marc A.
通讯作者：
Suchard, Marc A.
影响因子：
9.8
作者：
Drummond AJ;Ho SY;Phillips MJ;Rambaut A
通讯作者：
Rambaut A
影响因子：
10.7
作者：
Katoh K;Standley DM
通讯作者：
Standley DM
影响因子：
3.5
作者：
Eubank, S.;Eckstrand, I;Barrett, C. L.
通讯作者：
Barrett, C. L.