MicroRNAs: regulators of neuronal fate.
MicroRNAs: regulators of neuronal fate.
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DOI：
10.1016/j.ceb.2012.12.007
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发表时间：
2013-04
影响因子：
7.5
通讯作者：
Yoo, Andrew S.
中科院分区：
文献类型：
--
作者：
Sun, Alfred X.;Crabtree, Gerald R.;Yoo, Andrew S.
哺乳动物的神经发育传统上是在进化保守的信号通路和神经源性转录因子的背景下研究的。最近的研究表明，microRNAs作为一组高度保守的非编码调节性小rna，在神经发育和神经元功能中也发挥着重要作用。它们在发育中的神经系统中的部分作用是调节BAF复合物（atp依赖性染色质重塑复合物）的亚基组成，BAF复合物在神经发育过程中似乎具有专用功能。有趣的是，一组促进神经元特异性BAF复合物组装的脑富集microrna miR-9/9*和miR-124的异位表达，将人类真皮成纤维细胞的非神经元命运转变为有丝分裂后神经元，从而揭示了这些microrna以前未被认识到的指导作用。除了这些全局效应外，越来越多的证据表明，许多microrna也可能在局部发挥作用，例如在生长锥或调节突触活动和神经元连接的突触上。在这里，我们讨论了一些关于microrna在调节神经元不同发育阶段的活性的最新发现。
Mammalian neural development has been traditionally studied in the context of evolutionarily conserved signaling pathways and neurogenic transcription factors. Recent studies suggest that microRNAs, a group of highly conserved non-coding regulatory small RNAs also play essential roles in neural development and neuronal function. A part of their action in the developing nervous system is to regulate subunit compositions of BAF complexes (ATP-dependent chromatin remodeling complexes), which appear to have dedicated functions during neural development. Intriguingly, ectopic expression of a set of brain-enriched microRNAs, miR-9/9* and miR-124 that promote the assembly of neuron-specific BAF complexes, convert the nonneuronal fate of human dermal fibroblasts towards post-mitotic neurons, thereby revealing a previously unappreciated instructive role of these microRNAs. In addition to these global effects, accumulating evidence indicate that many microRNAs could also function locally, such as at the growth cone or at synapses modulating synaptic activity and neuronal connectivity. Here we discuss some of the recent findings about microRNAs’ activity in regulating various developmental stages of neurons.
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影响因子：
2.5
作者：
Kawase-Koga, Yoko;Otaegi, Gaizka;Sun, Tao
通讯作者：
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DOI：
10.1523/jneurosci.0558-12.2012
发表时间：
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期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
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作者：
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通讯作者：
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DOI：
10.1523/jneurosci.2390-08.2008
发表时间：
2008-12-31
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
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作者：
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影响因子：
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作者：
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