Evaluating breast cancer risk projections for Hispanic women.
Evaluating breast cancer risk projections for Hispanic women.
复制标题
DOI：
10.1007/s10549-011-1900-9
复制
发表时间：
2012-02
影响因子：
3.8
通讯作者：
Katki, Hormuzd A.
中科院分区：
文献类型：
--
作者：
Banegas, Matthew P.;Gail, Mitchell H.;LaCroix, Andrea;Thompson, Beti;Martinez, Maria Elena;Wactawski-Wende, Jean;John, Esther M.;Hubbell, F. Allan;Yasmeen, Shagufta;Katki, Hormuzd A.
对于西班牙裔妇女，乳腺癌风险评估工具（BCRAT;“盖尔模型”）结合了1990-1996年西班牙裔妇女乳腺癌发病率与非西班牙裔白色（NHW）妇女乳腺癌风险因素的相对风险。BCRAT风险预测从未对西班牙裔女性进行过全面评估。我们比较了妇女健康倡议（WHI）中6，353名西班牙裔和128，976名50岁及以上的NHW绝经后参与者的相对风险和BCRAT风险预测的校准。通过观察到的乳腺癌数量与BCRAT预期数量的比值（O/E）评估校准。我们重新评估了更新的BCRAT的校准，该BCRAT将BCRAT相对风险与1993-2007年与WHI同期的乳腺癌发病率相结合。考克斯回归用于估计相对风险。使用一致性统计（AUC）评估判别准确度。在WHI主要研究中，BCRAT低估了西班牙裔（O/E = 1.18，P = 0.06）和NHWs（O/E = 1.18，P < 0.001）中乳腺癌的数量18%。更新BCRAT改善了西班牙裔女性（O/E = 1.08，P = 0.4）和NHW女性（O/E = 0.98，P = 0.2）的校准。对于西班牙裔女性，乳腺活检次数（1.71 vs. 1.27，P = 0.03）和首次生育年龄（0.97 vs. 1.24，P = 0.02）的相对风险在WHI和BCRAT之间存在差异。西班牙裔女性的AUC高于NHW女性（0.63 vs. 0.58，P = 0.03）。用同期乳腺癌发病率更新BCRAT改善了WHI的校准。通过使用西班牙裔女性特有的风险因素相对风险，BCRAT对西班牙裔女性的适度歧视准确性可能会得到改善。
For Hispanic women, the Breast Cancer Risk Assessment Tool (BCRAT; “Gail Model”) combines 1990–1996 breast cancer incidence for Hispanic women with relative risks for breast cancer risk factors from non-Hispanic white (NHW) women. BCRAT risk projections have never been comprehensively evaluated for Hispanic women. We compared the relative risks and calibration of BCRAT risk projections for 6,353 Hispanic to 128,976 NHW postmenopausal participants aged 50 and older in the Women’s Health Initiative (WHI). Calibration was assessed by the ratio of the number of breast cancers observed with that expected by the BCRAT (O/E). We re-evaluated calibration for an updated BCRAT that combined BCRAT relative risks with 1993–2007 breast cancer incidence that is contemporaneous with the WHI. Cox regression was used to estimate relative risks. Discriminatory accuracy was assessed using the concordance statistic (AUC). In the WHI Main Study, the BCRAT underestimated the number of breast cancers by 18% in both Hispanics (O/E = 1.18, P = 0.06) and NHWs (O/E = 1.18, P < 0.001). Updating the BCRAT improved calibration for Hispanic women (O/E = 1.08, P = 0.4) and NHW women (O/E = 0.98, P = 0.2). For Hispanic women, relative risks for number of breast biopsies (1.71 vs. 1.27, P = 0.03) and age at first birth (0.97 vs. 1.24, P = 0.02) differed between the WHI and BCRAT. The AUC was higher for Hispanic women than NHW women (0.63 vs. 0.58, P = 0.03). Updating the BCRAT with contemporaneous breast cancer incidence rates improved calibration in the WHI. The modest discriminatory accuracy of the BCRAT for Hispanic women might improve by using risk factor relative risks specific to Hispanic women.
登录
查看更多内容
影响因子：
2.3
作者：
Risendal, Betsy;Hines, Lisa M.;Sweeney, Carol;Slattery, Martha L.;Giuliano, Anna R.;Baumgartner, Kathy B.;Curtin, Karen;Byers, Tim E.
通讯作者：
Byers, Tim E.
DOI：
10.1093/jnci/86.8.620
发表时间：
1994-04-20
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
BONDY, ML;LUSTBADER, ED;VOGEL, VG
通讯作者：
VOGEL, VG
影响因子：
2.3
作者：
Sweeney, Carol;Baumgartner, Kathy B.;Slattery, Martha L.
通讯作者：
Slattery, Martha L.
影响因子：
5.6
作者：
Ritenbaugh, C;Patterson, RE;Ockene, J
通讯作者：
Ockene, J
影响因子：
2.7
作者：
WIEAND, S;GAIL, MH;JAMES, KL
通讯作者：
JAMES, KL