Family history and age at onset of breast cancer in Hispanic and non-Hispanic white women.
Family history and age at onset of breast cancer in Hispanic and non-Hispanic white women.
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DOI：
10.1007/s10552-008-9206-x
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发表时间：
2008-12
影响因子：
2.3
通讯作者：
Byers, Tim E.
中科院分区：
文献类型：
--
作者：
Risendal, Betsy;Hines, Lisa M.;Sweeney, Carol;Slattery, Martha L.;Giuliano, Anna R.;Baumgartner, Kathy B.;Curtin, Karen;Byers, Tim E.
目的：评估西班牙裔和非西班牙裔白人(Nhw)女性乳腺癌家族史与乳腺癌风险之间的关系。Logistic回归模型被用来计算未调整和调整的优势比(OR)和95%的可信区间(CI)，这些数据来自四角乳腺癌研究，这是一项在美国西南部进行的基于人群的乳腺癌病例对照研究(3,074名nhw和1,647名西班牙裔女性)。在nhw和西班牙裔妇女中，乳腺癌家族史和早发性乳腺癌风险之间的关联不同。在50岁以上的女性中，有乳腺癌家族史与卫生保健工作者的风险增加有关，与拉美裔的OR为1.32(95%CI：0.82-2.19)相比，OR为2.34(95%CI：1.64-3.35)。在50岁及以上的女性中没有观察到这种风险差异，NHW的OR为1.69(95%CI：1.34-2.13)，西班牙裔为1.47(95%CI：1.03-2.10)。与拉美裔妇女相比，乳腺癌家族史在nhw人群中早发性乳腺癌的风险更大，可能反映了促进乳腺癌发展的某些易感基因因素的种族差异。
To evaluate the association between family history of breast cancer and breast cancer risk among Hispanic and non-Hispanic white (NHW) women. Logistic regression models were used to compute unadjusted and adjusted odds ratios (ORs) and 95% confidence intervals (CIs) using data collected from the 4-Corners Breast Cancer Study, a population-based case–control study of breast cancer conducted in the Southwest United States (3,074 NHW and 1,647 Hispanic women). The association between family history of breast cancer and early-onset breast cancer risk differs among NHW and Hispanic women. Among women<50 years old, having a family history of breast cancer was associated with a greater increase in risk among NHWs, with an OR of 2.34 (95% CI: 1.64–3.35) when compared to an OR of 1.32 (95% CI: 0.82–2.19) for Hispanics. This difference in risk was not observed among women 50 years and older, with an OR of 1.69 (95% CI: 1.34–2.13) for NHW and 1.47 (95% CI: 1.03–2.10) for Hispanics. Family history of breast cancer poses a greater risk for early-onset breast cancers among NHW when compared to Hispanic women and may reflect ethnic differences in certain predisposing genetic factors that promote breast cancer development.
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影响因子：
5
作者：
Sweeney, Carol;Edwards, Sandra L.;Slattery, Martha L.
通讯作者：
Slattery, Martha L.
影响因子：
2.3
作者：
Aldridge, ML;Daniels, JL;Jukic, AM
通讯作者：
Jukic, AM
影响因子：
--
作者：
Li, CI;Malone, KE;Daling, JR
通讯作者：
Daling, JR
影响因子：
3.8
作者：
Slattery, Martha L.;Sweeney, Carol;Byers, Tim
通讯作者：
Byers, Tim
影响因子：
5.3
作者：
McKean-Cowdin, R;Feigelson, HS;Henderson, BE
通讯作者：
Henderson, BE