Concise review: Insights from normal bone remodeling and stem cell-based therapies for bone repair.
Concise review: Insights from normal bone remodeling and stem cell-based therapies for bone repair.
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简洁的评论：正常骨骼重塑和基于干细胞的疗法的见解，用于骨修复。
DOI：
10.1002/stem.546
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发表时间：
2010-12
期刊：
影响因子：
5.2
通讯作者：
Moedder, Ulrike I.
中科院分区：
文献类型：
--
作者：
Khosla, Sundeep;Westendorf, Jennifer J.;Moedder, Ulrike I.
间充质干细胞在骨修复中的应用越来越受到关注。由于正常骨重建的一个主要原因是消除疲劳微裂纹，我们对这一过程的理解的进展可能会为促进骨折愈合提供信息。越来越多的证据表明，生理性骨重建发生在血管附近，这些血管携带血管周围干细胞，分化成成骨细胞。同样，骨折愈合严重依赖于血管的向内生长，不仅是为了营养供应，而且是为了成骨细胞的流入。许多动物和人类研究现已显示骨髓间充质干细胞在增强骨修复方面的潜在益处。然而，在其他组织中，这些细胞是否通过分化成骨细胞直接或间接通过分泌旁分泌因子募集血管和伴随的血管周围干细胞来改善骨折愈合的问题仍然是一个悬而未决的问题。此外，富含内皮/造血细胞的CD 34+细胞也在各种骨修复模型中显示出功效，至少部分是由于诱导血管生成和募集宿主祖细胞。因此，间充质和非间充质干/祖细胞是骨修复的有吸引力的选择。它们可能直接有助于骨修复，但也可能以适当的量和组合表达旁分泌因子，促进和维持愈合过程。
There is growing interest in the use of mesenchymal stem cells for bone repair. Since a major reason for normal bone remodeling is the removal of fatigue microcracks, advances in our understanding of this process may inform approaches to enhancing fracture healing. Increasing evidence now indicates that physiological bone remodeling occurs in close proximity to blood vessels and that these vessels carry perivascular stem cells that differentiate into osteoblasts. Similarly, fracture healing is critically dependent on the ingrowth of blood vessels not only for a nutrient supply, but also for the influx of osteoblasts. A number of animal and human studies have now shown the potential benefit of bone marrow-derived mesenchymal stem cells in enhancing bone repair. However, as in other tissues, the question of whether these cells improve fracture healing directly by differentiating into osteoblasts, or indirectly by secreting paracrine factors that recruit blood vessels and the accompanying perivascular stem cells remains a major unresolved issue. Moreover, CD34+ cells, which are enriched for endothelial/hematopoietic cells, have also shown efficacy in various bone repair models, at least in part due to the induction of angiogenesis and recruitment of host progenitor cells. Thus, mesenchymal and non-mesenchymal stem/progenitor cells are attractive options for bone repair. It is possible that they contribute directly to bone repair, but it is also likely that they express paracrine factors in the appropriate amounts and combinations that promote and sustain the healing process.
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影响因子：
24
作者：
Goessl, Mario;Moedder, Ulrike I.;Atkinson, Elizabeth J.;Lerman, Amir;Khosla, Sundeep
通讯作者：
Khosla, Sundeep
DOI：
10.1073/pnas.0608249103
发表时间：
2006-11-14
影响因子：
11.1
作者：
Lee, Ryang Hwa;Seo, Min Jeong;Prockop, Darwin J.
通讯作者：
Prockop, Darwin J.
影响因子：
158.5
作者：
Eghbali-Fatourechi, GZ;Lamsam, J;Khosla, S
通讯作者：
Khosla, S
影响因子：
--
作者：
Kadiyala, S;Jaiswal, N;Bruder, SP
通讯作者：
Bruder, SP
影响因子：
5.2
作者：
Mifune, Yutaka;Matsumoto, Tomoyuki;Asahara, Takayuki
通讯作者：
Asahara, Takayuki