Meta-Analysis of the Association between Mir-196a-2 Polymorphism and Cancer Susceptibility.
Meta-Analysis of the Association between Mir-196a-2 Polymorphism and Cancer Susceptibility.
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Mir-196a-2 多态性与癌症易感性关联的 Meta 分析
DOI：
10.3969/j.issn.2095-3941.2012.01.012
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发表时间：
2012-03
影响因子：
5.5
通讯作者：
Qian BY
中科院分区：
文献类型：
--
作者：
Zhang H;Su YL;Yu H;Qian BY
microRNA在基因表达中起着至关重要的作用，microRNA的失调参与了癌症的发生。据报道，miR-196 a-2多态性rs 11614913与癌症易感性相关。这项荟萃分析旨在评估miR-196 a-2与癌症风险的总体相关性。共有27项独立的病例对照研究，涉及10,435例病例和12,075例对照，分析了rs 11614913多态性。在四种遗传模型中发现rs 11614913多态性与癌症风险显著相关（CT与TT比较，OR=1.15，95%CI=1.05-1.27; CC与TT比较，OR=1.23，95%CI=1.08-1.39;显性模型OR=1.17，95%CI=1.06-1.30;相加模型OR=1.08，95%CI=1.01-1.14）。在不同肿瘤类型的亚组分析中，C等位基因与肺癌、乳腺癌和结直肠癌的风险增加相关，但与肝癌、胃癌或食管癌无关。在按种族进行的亚组分析中，在所有遗传模型中，亚洲人的癌症风险显著增加，但在高加索亚组中没有发现相关性。荟萃分析表明，miR-196 a-2多态性与癌症易感性相关，特别是在亚洲人群中肺癌，结直肠癌和乳腺癌。
MicroRNA plays a vital role in gene expression, and microRNA dysregulation is involved in carcinogenesis. The miR-196a-2 polymorphism rs11614913 is reportedly associated with cancer susceptibility. This meta-analysis was performed to assess the overall association of miR-196a-2 with cancer risk. A total of 27 independent case-control studies involving 10,435 cases and 12,075 controls were analyzed for the rs11614913 polymorphism. A significant association was found between rs11614913 polymorphism and cancer risk in four genetic models (CT vs. TT, OR=1.15, 95%CI=1.05–1.27; CC vs. TT, OR=1.23, 95%CI=1.08–1.39; Dominant model, OR=1.17, 95%CI=1.06–1.30; Additive model, OR=1.08, 95%CI=1.01–1.14). In the subgroup analysis of different tumor types, the C allele was associated with increased risk of lung, breast, and colorectal cancer, but not with liver, gastric, or esophageal cancer. In the subgroup analysis by ethnicity, a significantly increased risk of cancer was found among Asians in all genetic models, but no associations were found in the Caucasian subgroup. The meta-analysis demonstrated that the miR-196a-2 polymorphism is associated with cancer susceptibility, especially lung cancer, colorectal cancer, and breast cancer among Asian populations.
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影响因子：
7
作者：
Huedo-Medina, Tania B.;Sanchez-Meca, Julio;Botella, Juan
通讯作者：
Botella, Juan
影响因子：
56.9
作者：
Lagos-Quintana, M;Rauhut, R;Tuschl, T
通讯作者：
Tuschl, T
影响因子：
64.5
作者：
Han, Jinju;Lee, Yoontae;Kim, V. Narry
通讯作者：
Kim, V. Narry
影响因子：
3.5
作者：
Duan, Ranhui;Pak, ChangHui;Jin, Peng
通讯作者：
Jin, Peng
microRNA196a基因组区域的多态性与中国人群患神经胶质瘤的风险降低相关
DOI：
10.1007/s00432-010-0844-5
发表时间：
2010-12-01
影响因子：
3.6
作者：
Dou, Tonghai;Wu, Qihan;Lu, Daru
通讯作者：
Lu, Daru