Clinical characteristics, risk factors and outcomes of mixed Candida albicans/bacterial bloodstream infections.
Clinical characteristics, risk factors and outcomes of mixed Candida albicans/bacterial bloodstream infections.
复制标题
白色念珠菌/细菌血流混合感染的临床特征、危险因素和结果
DOI：
10.1186/s12879-020-05536-z
复制
发表时间：
2020-11-06
影响因子：
3.7
通讯作者：
Zhang G
中科院分区：
文献类型：
--
作者：
Zhong L;Zhang S;Tang K;Zhou F;Zheng C;Zhang K;Cai J;Zhou H;Wang Y;Tian B;Zhang Z;Cui W;Dong Z;Zhang G
目的
Purpose
The purpose of this study was to explore the clinical features, risk factors, and outcomes of mixed Candida albicans/bacterial bloodstream infections (mixed-CA/B-BSIs) compared with monomicrobial Candida albicans bloodstream infection (mono-CA-BSI) in adult patients in China.
Methods
All hospitalized adults with Candida albicans bloodstream infection (CA-BSI) were recruited for this retrospective observational study from January 1, 2013, to December 31, 2018.
Results
Of the 117 patients with CA-BSI, 24 patients (20.5%) had mixed-CA/B-BSIs. The most common copathogens were coagulase-negative Staphylococcus (CNS) (24.0%), followed by Klebsiella pneumoniae (20.0%) and Staphylococcus aureus (16.0%). In the multivariable analysis, a prior ICU stay 2 days (adjusted odds ratio [OR], 7.445; 95% confidence interval [CI], 1.152–48.132) was an independent risk factor for mixed-CA/B-BSIs. Compared with patients with mono-CA-BSI, patients with mixed-CA/B-BSIs had a prolonged length of mechanical ventilation [17.5 (4.5, 34.8) vs. 3.0 (0.0, 24.5), p = 0.019] and prolonged length of ICU stay [22.0 (14.3, 42.2) vs. 8.0 (0.0, 31.5), p = 0.010]; however, mortality was not significantly different.
Conclusions
There was a high rate of mixed-CA/B-BSIs cases among CA-BSI cases, and CNS was the predominant coexisting species. A prior ICU stay 2 days was an independent risk factor for mixed -CA/B-BSIs. Although there was no difference in mortality, the outcomes of patients with mixed -CA/B-BSIs, including prolonged length of mechanical ventilation and prolonged length of ICU stay, were worse than those with mono-CA-BSI; this deserves further attention from clinicians.
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DOI：
10.1111/j.1469-0691.2012.03906.x
发表时间：
2013-01
期刊：
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
影响因子：
--
作者：
Kim SH;Yoon YK;Kim MJ;Sohn JW
通讯作者：
Sohn JW
影响因子：
11.8
作者：
Ascioglu, S;Rex, JH;Walsh, TJ
通讯作者：
Walsh, TJ
DOI：
10.1016/j.cmi.2015.09.018
发表时间：
2016-01
期刊：
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
影响因子：
--
作者：
Rajendran R;Sherry L;Nile CJ;Sherriff A;Johnson EM;Hanson MF;Williams C;Munro CA;Jones BJ;Ramage G
通讯作者：
Ramage G
影响因子：
4.9
作者：
Harriott, Melphine M.;Noverr, Mairi C.
通讯作者：
Noverr, Mairi C.
影响因子：
4.9
作者：
Morrell, M;Fraser, VJ;Kollef, MH
通讯作者：
Kollef, MH