Direct brain recordings identify hippocampal and cortical networks that distinguish successful versus failed episodic memory retrieval.
Direct brain recordings identify hippocampal and cortical networks that distinguish successful versus failed episodic memory retrieval.
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DOI：
10.1016/j.neuropsychologia.2020.107595
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发表时间：
2020-10
期刊：
影响因子：
2.6
通讯作者：
Lega BC
中科院分区：
文献类型：
--
作者：
Tan RJ;Rugg MD;Lega BC
使用非侵入性成像技术收集的人类数据已经确立了顶叶区域对情景记忆提取的重要性，包括角回和后扣带皮层。这些区域构成了一个假定的核心情节检索网络的一部分。在自由回忆中，上下文适当和不适当的回忆事件（即先前的列表入侵）之间的比较提供了研究支持真实回忆的记忆提取网络的机会，现有的研究结果预测，这些脑区的电活动差异应根据回忆的准确性来确定。然而，以前的iEEG研究，主要利用硬膜下网格电极，没有充分的特点，在顶叶区域的大脑活动，在记忆检索，并没有检查核心回忆区和海马或前额叶皮层之间的连接。在这里，我们采用了从100名植入立体EEG电极的人类患者获得的数据集，用于癫痫发作映射目的，因为他们执行自由回忆任务。这个数据集使我们能够分别分析中线与侧顶叶脑区的活动，以及前海马与后海马的活动，以确定与提取相关的活动预测正确记忆与不正确记忆的回忆的区域。由于立体EEG方法的广泛覆盖，我们还能够检查区域间的连通性。我们的主要发现是，角回、楔前叶、后颞叶皮层和后海马（比前海马更多）的伽马带活动的差异区分了准确与不准确的回忆，以及主动提取与记忆搜索。左角回表现出显着的功率下降前列表入侵以及独特的相位-振幅耦合特性，而前额叶皮层是唯一的在列表入侵表现出功率增加。连接分析显示显着的半球不对称性，相对稀疏的左侧功能连接相比，右半球。这一发现的一个例外是前额叶皮层和左角回之间的连通性升高。这一发现被解释为前额叶皮层参与记忆监测和记忆决策的证据。
Human data collected using noninvasive imaging techniques have established the importance of parietal regions towards episodic memory retrieval, including the angular gyrus and posterior cingulate cortex. Such regions comprise part of a putative core episodic retrieval network. In free recall, comparisons between contextually appropriate and inappropriate recall events (i.e. prior list intrusions) provide the opportunity to study memory retrieval networks supporting veridical recall, and existing findings predict that differences in electrical activity in these brain regions should be identified according to the accuracy of recall. However, prior iEEG studies, utilizing principally subdural grid electrodes, have not fully characterized brain activity in parietal regions during memory retrieval and have not examined connectivity between core recollection areas and the hippocampus or prefrontal cortex. Here, we employed a data set obtained from 100 human patients implanted with stereo EEG electrodes for seizure mapping purposes as they performed a free recall task. This data set allowed us to separately analyze activity in midline versus lateral parietal brain regions, and in anterior versus posterior hippocampus, to identify areas in which retrieval–related activity predicted the recollection of a correct versus an incorrect memory. With the wide coverage afforded by the stereo EEG approach, we were also able to examine interregional connectivity. Our key findings were that differences in gamma band activity in the angular gyrus, precuneus, posterior temporal cortex, and posterior (more than anterior) hippocampus discriminated accurate versus inaccurate recall as well as active retrieval versus memory search. The left angular gyrus exhibited a significant power decrease preceding list intrusions as well as unique phase-amplitude coupling properties, whereas the prefrontal cortex was unique in exhibiting a power increase during list intrusions. Analysis of connectivity revealed significant hemispheric asymmetry, with relatively sparse left–sided functional connections compared to the right hemisphere. One exception to this finding was elevated connectivity between the prefrontal cortex and left angular gyrus. This finding is interpreted as evidence for the engagement of prefrontal cortex in memory monitoring and mnemonic decision–making.
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