Exposure to Medicines in the Family Medicine Cabinet: Is It a Harbinger of Later Opioid Dependence?
Exposure to Medicines in the Family Medicine Cabinet: Is It a Harbinger of Later Opioid Dependence?
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DOI：
10.1080/10826084.2020.1756856
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发表时间：
2020
影响因子：
2
通讯作者：
Cottler LB
中科院分区：
文献类型：
--
作者：
Elliott AL;Liu Y;Egan KL;Striley CW;Cottler LB
尽管对处方阿片类药物和依赖的研究是国家的优先事项，但对几种潜在的青少年风险因素与非医学使用阿片类药物的人后来对阿片类药物依赖之间的关系知之甚少。调查终身阿片类药物依赖与青少年自我感知健康、健康信念（认为所有事情都有一粒药）、健康行为（15岁前开始饮酒、15岁前开始使用处方阿片类药物）和父母健康实践（14岁时家庭药柜里有阿片类药物，父母建议生病时服用阿片类药物）之间的关系。在过去12个月中招募了343名非医疗使用处方阿片类药物的社区成员，进行处方药误用、滥用和依赖研究，并回顾性评估青少年终身阿片类药物依赖的风险因素（DSM-IV）。Logistic回归分析显示，14岁时在家庭药柜中使用处方阿片类药物是终生阿片类药物依赖的最强预测因子。那些从小就相信一切都有药片解决的人，以及那些在15岁之前就开始饮酒的人，达到依赖标准的可能性分别是同龄人的1.83倍和1.78倍。人口统计和其他青少年预测因素与阿片类药物依赖无关。研究结果表明，一些青少年暴露可以减少阿片类药物依赖。通过他们的行为，父母可以降低青少年对阿片类药物依赖的风险。
Despite research on prescription opioids and dependence being a national priority, little is known about the association between several potential adolescent risk factors and later opioid dependence among those who use opioids non-medically. To investigate the association between lifetime opioid dependence and adolescent self-perceived health, health beliefs (thinking there was a pill for everything), health behaviors (onset of alcohol use before 15, onset of prescription opioid use before 15) and parental health practices (having opioids in the family medicine cabinet at age 14, parental suggestions to take pills when sick). A sample of 343 community members who non-medically used prescription opioids in the past 12 months were recruited for the Prescription Drug Misuse, Abuse, and Dependence Study and retrospectively assessed for adolescent risk factors of lifetime opioid dependence (DSM-IV). Logistic regression revealed the strongest predictor of lifetime opioid dependence was having a prescription opioid in the family medicine cabinet at age 14. Those who grew up believing there was a pill for everything and those who initiated alcohol use before 15 were 1.83 and 1.78 times as likely, respectively, to meet dependence criteria than their counterparts. Demographics and other adolescent predictors were not associated with opioid dependence. Findings suggest several adolescent exposures can be targeted to reduce opioid dependence. Through their behavior, parents can reduce their teens’ risk for opioid dependence.
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影响因子：
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作者：
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