Red blood cell folate and plasma folate are not associated with risk of incident colorectal cancer in the Women's Health Initiative observational study.
Red blood cell folate and plasma folate are not associated with risk of incident colorectal cancer in the Women's Health Initiative observational study.
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DOI：
10.1002/ijc.29453
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发表时间：
2015-08-15
影响因子：
6.4
通讯作者：
Ulrich, Cornelia M.
中科院分区：
文献类型：
--
作者：
Neuhouser, Marian L.;Cheng, Ting-Yuan David;Beresford, Shirley A. A.;Brown, Elissa;Song, Xiaoling;Miller, Joshua W.;Zheng, Yingye;Thomson, Cynthia A.;Shikany, James M.;Vitolins, Mara Z.;Rohan, Thomas;Green, Ralph;Ulrich, Cornelia M.
叶酸和结直肠癌（CRC）风险之间的关系尚不清楚。我们在妇女健康倡议观察性研究（WHI-OS）中采用巢式病例对照设计，调查了叶酸状态的两种生物标志物，血浆叶酸和红细胞（RBC）叶酸与CRC风险的相关性。年龄50-79岁的绝经后女性（n= 93，676）入组WHI-OS（1993-1998）。在入组时收集空腹抽血和广泛的健康、饮食和生活方式数据。截至2008年，报告了988例CRC事件，并通过医疗记录裁定予以确认。病例组和对照组在年龄（± 3岁）、入组日期（± 1岁）、人种/种族、抽血日期（± 6个月）和子宫切除术状态方面匹配。通过放射性测定法测定血浆和RBC叶酸。将叶酸生物标志物值分为四分位数，条件Logistic回归估计叶酸与总CRC相关性的比值比（OR）和95%置信区间（CI），按肿瘤部位和诊断时的分期。其他分析检查了与美国叶酸强化政策相对应的不同时期的风险是否不同：强化前（1994-95），强化前后（1996-97）和强化后（1998）。比较Q4与Q1，RBC和血浆叶酸的总体CRC风险OR分别为0.91（95% CI 0.67-1.24）和0.91（95% CI 0.67-1.23）。食物强化的风险没有变化。这些结果并不支持叶酸与CRC风险的整体关联，并表明美国食品供应中的叶酸强化并没有改变这些绝经后妇女的相关性。
The relationship between folate and colorectal cancer (CRC) risk is unclear. We investigated the association of two biomarkers of folate status, plasma folate and red blood cell (RBC) folate with CRC risk using a nested case-control design in the Women’s Health Initiative Observational Study (WHI-OS). Postmenopausal women (n=93,676) aged 50–79 years were enrolled in the WHI-OS (1993–1998). A fasting blood draw and extensive health, dietary and lifestyle data were collected upon enrollment. Through 2008, 988 incident CRC cases were reported and confirmed with medical records adjudication. Cases and controls were matched on age (± 3 y), enrollment date (± 1 y), race/ethnicity, blood draw date (± 6 mo) and hysterectomy status. Plasma and RBC folate were determined by radioassay. Folate biomarker values were divided into quartiles and conditional logistic regression estimated odds ratios (ORs) and 95% confidence intervals (CI) for the associations of folate with total CRC, by tumor site and by stage at diagnosis. Additional analyses examined whether risks varied across time periods corresponding to the United States folic acid fortification policy: pre-fortification (1994–95), peri-fortification (1996–97) and post-fortification (1998). ORs for overall CRC risk comparing Q4 vs. Q1 were 0.91 (95% CI 0.67–1.24) and 0.91 (95% CI 0.67–1.23) for RBC and plasma folate, respectively. There were no changes in risk attributable to food supply fortification. These results do not support an overall association of folate with CRC risk and suggest that folic acid fortification of the U.S. food supply did not alter the associations in these postmenopausal women.
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影响因子：
5.6
作者：
Nan, Hongmei;Lee, Jung Eun;Rimm, Eric B.;Fuchs, Charles S.;Giovannucci, Edward L.;Cho, Eunyoung
通讯作者：
Cho, Eunyoung
影响因子：
2.3
作者：
Lee, Jung Eun;Wei, Esther K.;Giovannucci, Edward
通讯作者：
Giovannucci, Edward
影响因子：
2.3
作者：
Kim, Dong-Hyun;Smith-Warner, Stephanie A.;Spiegelman, Donna;Yaun, Shiaw-Shyuan;Colditz, Graham A.;Freudenheim, Jo L.;Giovannucci, Edward;Goldbohm, R. Alexandra;Graham, Saxon;Harnack, Lisa;Jacobs, Eric J.;Leitzmann, Michael;Mannisto, Satu;Miller, Anthony B.;Potter, John D.;Rohan, Thomas E.;Schatzkin, Arthur;Speizer, Frank E.;Stevens, Victoria L.;Stolzenberg-Solomon, Rachael;Terry, Paul;Toniolo, Paolo;Weijenberg, Matty P.;Willett, Walter C.;Wolk, Alicja;Zeleniuch-Jacquotte, Anne;Hunter, David J.
通讯作者：
Hunter, David J.
影响因子：
5.6
作者：
Anderson, GL;Manson, J;Prentice, RL
通讯作者：
Prentice, RL
影响因子：
3.8
作者：
Mason, Joel B.;Dickstein, Aaron;Rosenberg, Irwin H.
通讯作者：
Rosenberg, Irwin H.