Pooled analyses of 13 prospective cohort studies on folate intake and colon cancer.
Pooled analyses of 13 prospective cohort studies on folate intake and colon cancer.
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DOI：
10.1007/s10552-010-9620-8
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发表时间：
2010-11
影响因子：
2.3
通讯作者：
Hunter, David J.
中科院分区：
文献类型：
--
作者：
Kim, Dong-Hyun;Smith-Warner, Stephanie A.;Spiegelman, Donna;Yaun, Shiaw-Shyuan;Colditz, Graham A.;Freudenheim, Jo L.;Giovannucci, Edward;Goldbohm, R. Alexandra;Graham, Saxon;Harnack, Lisa;Jacobs, Eric J.;Leitzmann, Michael;Mannisto, Satu;Miller, Anthony B.;Potter, John D.;Rohan, Thomas E.;Schatzkin, Arthur;Speizer, Frank E.;Stevens, Victoria L.;Stolzenberg-Solomon, Rachael;Terry, Paul;Toniolo, Paolo;Weijenberg, Matty P.;Willett, Walter C.;Wolk, Alicja;Zeleniuch-Jacquotte, Anne;Hunter, David J.
叶酸摄入量和结直肠癌风险的研究一直不一致。我们在一系列13项前瞻性研究中检查了与结肠癌风险的关系。使用考克斯比例风险模型从原始数据估计研究和性别特异性相对风险（RR），然后使用随机效应模型汇总。在725，134名参与者中，有5，720例结肠癌在随访期间被诊断出来。比较摄入量最高与最低五分位数的汇总多变量RR（95%置信区间[CI]）为0.92（95% CI 0.84-1.00，p值，研究间异质性检验= 0.85）（膳食叶酸）和0.85（95% CI 0.77-0.95，p值，研究间异质性检验= 0.42）（总叶酸）。在使用绝对摄入临界点的分析中，总叶酸摄入量的结果相似（汇总多变量RR = 0.87，95% CI 0.78-0.98，比较≥560 mcg/天与<240 mcg/天，p值，趋势检验= 0.009）。当作为连续变量进行分析时，估计叶酸总摄入量每增加100 μg/天，风险降低2%（95%CI 0-3%）。这些数据支持这一假设，即较高的叶酸摄入量与结肠癌风险降低适度相关。
Studies of folate intake and colorectal cancer risk have been inconsistent. We examined the relation with colon cancer risk in a series of 13 prospective studies. Study- and sex-specific relative risks (RRs) were estimated from the primary data using Cox proportional hazards models and then pooled using a random-effects model. Among 725,134 participants, 5,720 incident colon cancers were diagnosed during follow-up. The pooled multivariate RRs (95% confidence interval [CI]) comparing the highest vs. lowest quintile of intake were 0.92 (95% CI 0.84–1.00, p-value, test for between-studies heterogeneity = 0.85) for dietary folate and 0.85 (95% CI 0.77–0.95, p-value, test for between-studies heterogeneity = 0.42) for total folate. Results for total folate intake were similar in analyses using absolute intake cutpoints (pooled multivariate RR = 0.87, 95% CI 0.78–0.98, comparing ≥560 mcg/days vs. <240 mcg/days, p-value, test for trend = 0.009). When analyzed as a continuous variable, a 2% risk reduction (95% CI 0–3%) was estimated for every 100 μg/day increase in total folate intake. These data support the hypothesis that higher folate intake is modestly associated with reduced risk of colon cancer.
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影响因子：
2.3
作者：
Bandera, EV;Freudenheim, JL;Graham, S
通讯作者：
Graham, S
DOI：
10.1073/pnas.94.7.3290
发表时间：
1997-04-01
影响因子：
11.1
作者：
Blount, BC;Mack, MM;Ames, BN
通讯作者：
Ames, BN
影响因子：
6.7
作者：
Duthie, SJ
通讯作者：
Duthie, SJ
影响因子：
7.1
作者：
FRANCIS, KT;THOMPSON, RW;KRUMDIECK, CL
通讯作者：
KRUMDIECK, CL
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N