Prospective study of alcohol consumption and the risk of colorectal cancer before and after folic acid fortification in the United States.
Prospective study of alcohol consumption and the risk of colorectal cancer before and after folic acid fortification in the United States.
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DOI：
10.1016/j.annepidem.2013.04.011
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发表时间：
2013-09
影响因子：
5.6
通讯作者：
Cho, Eunyoung
中科院分区：
文献类型：
--
作者：
Nan, Hongmei;Lee, Jung Eun;Rimm, Eric B.;Fuchs, Charles S.;Giovannucci, Edward L.;Cho, Eunyoung
根据美国叶酸强化期评价饮酒对结直肠癌风险的影响。我们在两项前瞻性队列研究（女性护士健康研究（NHS）和男性健康专业人员随访研究（HPFS））中，通过强化期（1998年之前与1998年之后）评估了饮酒与结直肠癌之间的关联，其中记录了2，793例浸润性结直肠癌病例。饮酒与结直肠癌风险增加有关。在不使用多种维生素和/或叶酸补充剂的人群中，≥ 30 g/d饮酒者与不饮酒者的合并多变量相对风险（RR）为1.36（95% CI，1.09-1.70;趋势p，0.02）。在叶酸强化前阶段，饮酒的影响略强（1980 NHS/1986 HPFS-1998）（1998-2008）; ≥ 30 g/d饮酒者与不饮酒者的合并多变量RR为1.31（95% CI，1.00-1.71;趋势p，0.10），强化前和强化后分别为1.07（95% CI，0.69-1.65;趋势p，0.67）。叶酸强化可以减轻大量饮酒对结直肠癌风险的不利影响。
To evaluate the influence of alcohol consumption on the risk of colorectal cancer according to folic acid fortification period in the United States. We evaluated the association between alcohol consumption and colorectal cancer by fortification period (before 1998 vs. after 1998) in two prospective cohort studies, Nurses’ Health Study (NHS) of women and Health Professionals Follow-up Study (HPFS) of men, in which 2,793 invasive colorectal cancer cases were documented. Alcohol consumption was associated with an increased risk of colorectal cancer. Among non-users of multivitamins and/or folic acid supplements, the pooled multivariate relative risk (RR) for ≥30g/d drinkers versus non-drinkers was 1.36 (95% CI, 1.09–1.70; p for trend, 0.02). The effect of alcohol consumption was slightly stronger in the pre-folic acid fortification period (1980 NHS/1986 HPFS-1998) than in the post-fortification period (1998–2008); the pooled multivariate RRs for ≥30g/d drinkers versus non-drinkers were 1.31 (95% CI, 1.00–1.71; p for trend, 0.10) in the pre-fortification period and 1.07 (95% CI, 0.69–1.65; p for trend, 0.67) in the post-fortification period. Folic acid fortification may attenuate the adverse effect of high alcohol consumption on the risk of colorectal cancer.
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影响因子：
4.2
作者：
Giovannucci, E
通讯作者：
Giovannucci, E
影响因子：
2.9
作者：
Harnack, L;Jacobs, DR;Folsom, AR
通讯作者：
Folsom, AR
影响因子：
4.2
作者：
Choi, SW;Mason, JB
通讯作者：
Mason, JB
DOI：
10.1006/bbrc.1993.1750
发表时间：
1993-06-30
影响因子：
3.1
作者：
BALAGHI, M;WAGNER, C
通讯作者：
WAGNER, C
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N