Moving from nature to nurture: a systematic review and meta-analysis of environmental factors associated with juvenile idiopathic arthritis.
Moving from nature to nurture: a systematic review and meta-analysis of environmental factors associated with juvenile idiopathic arthritis.
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DOI：
10.1093/rheumatology/keab627
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发表时间：
2022-02-02
期刊：
影响因子：
--
通讯作者：
Ramanan AV
中科院分区：
文献类型：
--
作者：
Clarke SLN;Mageean KS;Maccora I;Harrison S;Simonini G;Sharp GC;Relton CL;Ramanan AV
JIA是最常见的儿童风湿性疾病，被认为是受遗传和环境的影响。识别与疾病风险相关的环境因素将提高对疾病机制的认识，并最终使患者受益。本文旨在整理和综合目前与JIA相关的环境因素的证据。从开始到2020年1月，检索了4个数据库（MEDLINE、Embase、Web of Science和Cumulative Index to Nursing and Allied Health Literature）。研究质量采用Newcastle-Ottawa量表进行评定。在可能的情况下，使用随机效应、逆方差方法生成每个环境因素的汇总估计值。其余的环境因素以叙述的形式加以综合。本综述包括45年来39项研究（11项队列研究和28项病例对照研究）的66项环境因素。研究样本量从41到190万参与者不等。对10项研究的8个环境因素进行了荟萃分析。剖腹产与JIA风险增加相关[合并比值比（OR）1.11，95% CI：1.01，1.22]。相反，兄弟姐妹（合并OR 0.60，95% CI：0.44，0.81）和母亲产前吸烟（合并OR 0.70，95% CI：0.58，0.84）的存在（与不存在）与JIA风险降低。这篇综述确定了与JIA相关的几个环境因素，并展示了五十多年来进行的环境研究的巨大广度。我们还强调了由于研究可比性有限，医疗保健和社会实践的演变以及不断变化的环境，在计划未来研究时需要考虑合并这一时期收集的数据的挑战。
JIA is the most common paediatric rheumatic disease, thought to be influenced by both genetics and the environment. Identifying environmental factors associated with disease risk will improve knowledge of disease mechanism and ultimately benefit patients. This review aimed to collate and synthesize the current evidence of environmental factors associated with JIA. Four databases (MEDLINE, Embase, Web of Science and Cumulative Index to Nursing and Allied Health Literature) were searched from inception to January 2020. Study quality was rated using the Newcastle-Ottawa Scale. Pooled estimates for each environmental factor were generated using a random-effects, inverse-variance method, where possible. The remaining environmental factors were synthesized in narrative form. This review includes 66 environmental factors from 39 studies (11 cohort and 28 case-control studies) over 45 years. Study sample sizes ranged from 41 to 1.9 million participants. Eight environmental factors from ten studies were meta-analysed. Caesarean section delivery was associated with increased JIA risk [pooled odds ratio (OR) 1.11, 95% CI: 1.01, 1.22]. Conversely, presence (vs absence) of siblings (pooled OR 0.60, 95% CI: 0.44, 0.81) and maternal prenatal smoking (pooled OR 0.70, 95% CI: 0.58, 0.84) were associated with decreased JIA risk. This review identifies several environmental factors associated with JIA and demonstrates the huge breadth of environmental research undertaken over five decades. We also highlight the challenges of combining data collected over this period due to limited between study comparability, evolution in healthcare and social practices, and changing environment, which warrant consideration when planning future studies.
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影响因子：
30.8
作者：
Hinks, Anne;Cobb, Joanna;Marion, Miranda C.;Prahalad, Sampath;Sudman, Marc;Bowes, John;Martin, Paul;Comeau, Mary E.;Sajuthi, Satria;Andrews, Robert;Brown, Milton;Chen, Wei-Min;Concannon, Patrick;Deloukas, Panos;Edkins, Sarah;Eyre, Stephen;Gaffney, Patrick M.;Guthery, Stephen L.;Guthridge, Joel M.;Hunt, Sarah E.;James, Judith A.;Keddache, Mehdi;Moser, Kathy L.;Nigrovic, Peter A.;Onengut-Gumuscu, Suna;Onslow, Mitchell L.;Rose, Carlos D.;Rich, Stephen S.;Steel, Kathryn J. A.;Wakeland, Edward K.;Wallace, Carol A.;Wedderburn, Lucy R.;Woo, Patricia;Bohnsack, John F.;Haas, Johannes Peter;Glass, David N.;Langefeld, Carl D.;Thomson, Wendy;Thompson, Susan D.
通讯作者：
Thompson, Susan D.
影响因子：
5
作者：
GREENLAND, S;LONGNECKER, MP
通讯作者：
LONGNECKER, MP
影响因子：
3.9
作者：
Arvonen, Miika;Virta, Lauri J.;Vahasalo, Paula
通讯作者：
Vahasalo, Paula
影响因子：
158.5
作者：
CHANTLER, JK;TINGLE, AJ;PETTY, RE
通讯作者：
PETTY, RE
DOI：
10.1097/nmc.0000000000000373
发表时间：
2017
期刊：
MCN. The American journal of maternal child nursing
影响因子：
--
作者：
Dunn AB;Jordan S;Baker BJ;Carlson NS
通讯作者：
Carlson NS