Viable SARS-CoV-2 Delta variant detected in aerosols in a residential setting with a self-isolating college student with COVID-19.
Viable SARS-CoV-2 Delta variant detected in aerosols in a residential setting with a self-isolating college student with COVID-19.
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DOI：
10.1016/j.jaerosci.2022.106038
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发表时间：
2022-09
影响因子：
4.5
通讯作者：
Wu, Chang-Yu
中科院分区：
文献类型：
--
作者：
Vass, William B.;Lednicky, John A.;Shankar, Sripriya Nannu;Fan, Z. Hugh;Eiguren-Fernandez, Arantzazu;Wu, Chang-Yu
SARS-CoV-2的B.1.617.2（Delta）变体于2020年10月在印度出现，并广泛传播到超过145个国家，截至2021年9月，美国COVID-19病例中超过99%的基因组序列确认病毒。由于Delta变异导致的COVID-19病例增加，恰逢学校恢复亲自上课，这使教育机构实施的COVID-19缓解计划受到压力。一些计划要求患病学生在校外自我隔离，这导致了一个意想不到的后果：病人在隔离期间使用的住所的共同居民暴露。我们评估了从一名患有轻度COVID-19的自我隔离大学生的卧室收集的空气和表面样本，以确定是否存在SARS-CoV-2。通过实时逆转录定量聚合酶链反应（rRT-qPCR）在同一住所的隔离卧室和远端非隔离房间的空气样本中检测到该病毒的RNA。检测到SARS-CoV-2，并从气溶胶样本以及移动的手机表面的细胞培养物中分离出活病毒。基因组测序显示，该病毒是Delta变异SARS-CoV-2毒株。综上所述，这项工作的结果证实了在COVID-19患者的住宅生活空间内存在可行的SARS-CoV-2，并显示了将载有病毒的气溶胶运输到指定隔离套房之外的单户住宅的其他区域的可能性。
The B.1.617.2 (Delta) variant of SARS-CoV-2 emerged in India in October of 2020 and spread widely to over 145 countries, comprising over 99% of genome sequence-confirmed virus in COVID-19 cases of the United States (US) by September 2021. The rise in COVID-19 cases due to the Delta variant coincided with a return to in-person school attendance, straining COVID-19 mitigation plans implemented by educational institutions. Some plans required sick students to self-isolate off-campus, resulting in an unintended consequence: exposure of co-inhabitants of dwellings used by the sick person during isolation. We assessed air and surface samples collected from the bedroom of a self-isolating university student with mild COVID-19 for the presence of SARS-CoV-2. That virus’ RNA was detected by real-time reverse-transcription quantitative polymerase chain reaction (rRT-qPCR) in air samples from both an isolation bedroom and a distal, non-isolation room of the same dwelling. SARS-CoV-2 was detected and viable virus was isolated in cell cultures from aerosol samples as well as from the surface of a mobile phone. Genomic sequencing revealed that the virus was a Delta variant SARS-CoV-2 strain. Taken together, the results of this work confirm the presence of viable SARS-CoV-2 within a residential living space of a person with COVID-19 and show potential for transportation of virus-laden aerosols beyond a designated isolation suite to other areas of a single-family home.
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DOI：
10.1016/j.lanepe.2021.100252
发表时间：
2022-01
期刊：
The Lancet regional health. Europe
影响因子：
--
作者：
Allen H;Vusirikala A;Flannagan J;Twohig KA;Zaidi A;Chudasama D;Lamagni T;Groves N;Turner C;Rawlinson C;Lopez-Bernal J;Harris R;Charlett A;Dabrera G;Kall M;COVID-19 Genomics UK (COG-UK Consortium)
通讯作者：
COVID-19 Genomics UK (COG-UK Consortium)
DOI：
10.1503/cmaj.211248
发表时间：
2021-10-25
期刊：
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
影响因子：
--
作者：
Fisman DN;Tuite AR
通讯作者：
Tuite AR
影响因子：
4
作者：
Ahlawat, Ajit;Wiedensohler, Alfred;Mishra, Sumit Kumar
通讯作者：
Mishra, Sumit Kumar
影响因子：
11.8
作者：
Fears, Alyssa C.;Klimstra, William B.;Roy, Chad J.
通讯作者：
Roy, Chad J.
影响因子：
4.6
作者：
Kasloff SB;Leung A;Strong JE;Funk D;Cutts T
通讯作者：
Cutts T