Household transmission of COVID-19 cases associated with SARS-CoV-2 delta variant (B.1.617.2): national case-control study.
Household transmission of COVID-19 cases associated with SARS-CoV-2 delta variant (B.1.617.2): national case-control study.
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DOI：
10.1016/j.lanepe.2021.100252
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发表时间：
2022-01
期刊：
影响因子：
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通讯作者：
COVID-19 Genomics UK (COG-UK Consortium)
中科院分区：
文献类型：
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作者：
Allen H;Vusirikala A;Flannagan J;Twohig KA;Zaidi A;Chudasama D;Lamagni T;Groves N;Turner C;Rawlinson C;Lopez-Bernal J;Harris R;Charlett A;Dabrera G;Kall M;COVID-19 Genomics UK (COG-UK Consortium)
首先在印度发现的SARS-CoV-2 Delta变体（B.1.617.2）已迅速成为英国的主要变体。早期的报告表明，这种变体具有增加的生长速度，这表明增加了遗传性。本研究间接评估了新出现的Delta变体与先前显性的Alpha变体之间的遗传性差异（B.1.1.7）。进行了一项匹配的病例对照研究，以估计Delta变异指数病例与Alpha病例相比的家庭传播几率（14天内≥ 2例）。病例来源于国家监测数据（2021年3月至6月）。对居住地地理位置、检测时间段和房产类型进行一对二匹配，并采用多变量条件逻辑回归模型进行分析。在家庭集群中共有5，976例基因组测序的索引病例与11，952例散发索引病例（家庭中的单个病例）相匹配。43.3%（n= 2，586）的家庭聚集性病例被确认为Delta变异，而40.4%（n= 4，824）的散发病例被确认为Delta变异。在调整了年龄、性别、种族、多重剥夺指数（IMD）、家庭接触人数和指示病例的疫苗接种情况后，Delta变异病例与Alpha病例之间的家庭传播优势比为1.70（95% CI 1.48-1.95，p <0.001）。我们发现了SARS-CoV-2 Delta变异体家庭传播增加的证据，这可能解释了它在取代Alpha变异体成为英格兰优势毒株方面的成功。随着Delta变异现在已在世界上许多国家被检测到，了解这种变异的传播性对于在国际上为感染预防和控制政策提供信息非常重要。
The SARS-CoV-2 Delta variant (B.1.617.2), first detected in India, has rapidly become the dominant variant in England. Early reports suggest this variant has an increased growth rate suggesting increased transmissibility. This study indirectly assessed differences in transmissibility between the emergent Delta variant compared to the previously dominant Alpha variant (B.1.1.7). A matched case-control study was conducted to estimate the odds of household transmission (≥ 2 cases within 14 days) for Delta variant index cases compared with Alpha cases. Cases were derived from national surveillance data (March to June 2021). One-to-two matching was undertaken on geographical location of residence, time period of testing and property type, and a multivariable conditional logistic regression model was used for analysis. In total 5,976 genomically sequenced index cases in household clusters were matched to 11,952 sporadic index cases (single case within a household). 43.3% (n=2,586) of cases in household clusters were confirmed Delta variant compared to 40.4% (n= 4,824) of sporadic cases. The odds ratio of household transmission was 1.70 among Delta variant cases (95% CI 1.48-1.95, p <0.001) compared to Alpha cases after adjusting for age, sex, ethnicity, index of multiple deprivation (IMD), number of household contacts and vaccination status of index case. We found evidence of increased household transmission of SARS-CoV-2 Delta variant, potentially explaining its success at displacing Alpha variant as the dominant strain in England. With the Delta variant now having been detected in many countries worldwide, the understanding of the transmissibility of this variant is important for informing infection prevention and control policies internationally.
DOI：
10.3390/ijerph18157752
发表时间：
2021-07-22
影响因子：
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作者：
Tanaka H;Hirayama A;Nagai H;Shirai C;Takahashi Y;Shinomiya H;Taniguchi C;Ogata T
通讯作者：
Ogata T
DOI：
10.1056/nejmoa2108891
发表时间：
2021-08-12
期刊：
The New England journal of medicine
影响因子：
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作者：
Lopez Bernal J;Andrews N;Gower C;Gallagher E;Simmons R;Thelwall S;Stowe J;Tessier E;Groves N;Dabrera G;Myers R;Campbell CNJ;Amirthalingam G;Edmunds M;Zambon M;Brown KE;Hopkins S;Chand M;Ramsay M
通讯作者：
Ramsay M
DOI：
10.1016/j.jinf.2021.07.037
发表时间：
2021-10
期刊：
The Journal of infection
影响因子：
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作者：
Miller E;Waight PA;Andrews NJ;McOwat K;Brown KE;Höschler K;Ijaz S;Letley L;Haskins D;Sinnathamby M;Cuthbertson H;Hallis B;Parimalanathan V;de Lusignan S;Lopez-Bernal J
通讯作者：
Lopez-Bernal J