Adverse childhood experiences associate with early post-trauma thalamus and thalamic nuclei volumes and PTSD development in adulthood.
Adverse childhood experiences associate with early post-trauma thalamus and thalamic nuclei volumes and PTSD development in adulthood.
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DOI：
10.1016/j.pscychresns.2021.111421
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发表时间：
2022-01
期刊：
影响因子：
--
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Xie H;Huffman N;Shih CH;Cotton AS;Buehler M;Brickman KR;Wall JT;Wang X
童年不良经历（ACEs）可能会在成年后遭遇创伤时促使创伤后应激障碍（PTSD）的发生，但潜在的大脑变化仍不明确。本研究对童年不良经历、丘脑整体及丘脑核体积，以及成年创伤后的创伤后应激症状（PTSS）之间的关系进行了测试。101名创伤幸存者在创伤后2周内完成了儿童期创伤问卷（CTQ）、创伤后应激障碍检查表——特殊应激源版本5（PCL），以及一次结构磁共振成像（sMRI）扫描。在创伤后3个月，幸存者完成了第二次PCL调查，并使用临床医生管理的创伤后应激障碍量表（CAPS）进行了创伤后应激障碍诊断访谈。CTQ得分与创伤后2周和3个月时的PCL得分呈显著正相关（p值分别<0.01和<0.001）。在创伤后2周，CTQ得分与创伤后应激障碍组（n = 50）的丘脑整体及7个丘脑核体积呈显著负相关，但在非创伤后应激障碍组（n = 51）中并非如此。在创伤后3个月，丘脑整体及22个核体积与创伤后应激障碍组的PCL得分呈显著负相关，但在非创伤后应激障碍组中并非如此。这些结果表明，童年不良经历对创伤后早期的丘脑体积有负面影响，而这反过来又与患上创伤后应激障碍的幸存者的创伤后应激症状呈负相关。
Adverse childhood experiences (ACEs) potentially contribute to posttraumatic stress disorder (PTSD) after adult trauma exposure, but underlying brain changes remain unclear. The present study tested relationships between ACEs, whole thalamus and thalamic nuclei volumes, and post-trauma stress symptoms (PTSS) after adult trauma. Trauma survivors (n=101) completed the Childhood Trauma Questionnaire (CTQ), the PTSD checklist-special stressor version 5 (PCL), and a structural magnetic resonance imaging (sMRI) scan within post-trauma 2 weeks. At post-trauma 3 months, survivors completed a second PCL survey and a PTSD diagnosis interview using the Clinician-Administered PTSD Scale (CAPS). CTQ scores significantly positively correlated with PCL scores at post-trauma 2 weeks and 3 months (respective p’s < 0.01 and < 0.001). CTQ scores significantly negatively correlated with whole thalamus and 7 thalamic nuclei volumes at post-trauma 2 weeks in the PTSD (N=50), but not the non-PTSD (N=51) group. Whole thalamus and 22 nuclei volumes significantly negatively correlated with PCL scores at post-trauma 3 months in the PTSD, but not the non-PTSD group. These results suggest ACEs negatively influence early post-trauma thalamic volumes which, in turn, are negatively associated with PTSS in survivors who develop PTSD.
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