The Evaluation of Coffee Therapy for Improvement of Renal Oxygenation (COFFEE) Study: A Mechanistic Pilot and Feasibility Study Evaluating Coffee's Effects on Intrarenal Hemodynamic Function and Renal Energetics.
The Evaluation of Coffee Therapy for Improvement of Renal Oxygenation (COFFEE) Study: A Mechanistic Pilot and Feasibility Study Evaluating Coffee's Effects on Intrarenal Hemodynamic Function and Renal Energetics.
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咖啡治疗改善肾氧合（Coffee）研究的评价：评价咖啡对肾内血流动力学功能和肾能量学影响的机制试点和可行性研究。
DOI：
10.1016/j.ekir.2022.04.096
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发表时间：
2022-07
影响因子：
6
通讯作者：
Bjornstad, Petter
中科院分区：
文献类型：
--
作者：
Tommerdahl, Kalie L.;Vinovskis, Carissa;Li, Lu-Ping;Rebholz, Casey M.;Severn, Cameron;Hu, Emily A.;Selvin, Elizabeth;Coresh, Josef;Grams, Morgan E.;Prasad, Pottumarthi;Parikh, Chirag R.;Bjornstad, Petter
咖啡仍然是美国消费最广泛的饮料之一，估计每天摄入4亿杯。广泛的研究揭示了咖啡消费带来的各种健康益处，在对涉及208，501名成年人的3项大型前瞻性研究的荟萃分析中，含咖啡因和不含咖啡因的咖啡消费与全因死亡率的风险降低有关。2.喝咖啡对生存有好处的一个可能的解释是预防肾脏疾病。事实上，习惯性咖啡消费与社区研究中慢性肾病（CKD）的发病率较低有关，这是一项针对14，209名老年人的大型人群研究。3然而，咖啡对肾脏功能的特定生理作用可能有助于改善发病率和死亡率尚未阐明。普通咖啡含有多种潜在的肾脏修饰化合物，包括咖啡因，一种甲基黄嘌呤生物碱，可作为腺苷受体的拮抗剂，4和多酚生物活性化合物，可作为植物基抗氧化剂。5已发现咖啡因通过抑制近端和远端小管钠重吸收以促进游离水和溶质排泄以及改变肾素-血管紧张素-醛固酮系统等因素来改变肾脏血流动力学和尿钠排泄。4，6在对钠输送到远端小管的反应中，咖啡因也被假设抑制肾小管肾小球反馈反应，并可能维持肾小球滤过率（GFR）和肾血浆流量（RPF），同时减少肾氧（O 2）的消耗。与咖啡因的有益作用相结合，咖啡中的生物活性化合物也被发现可以改善氧化应激和炎症，这是已知的肾损伤因素。5，7然而，迄今为止，尚无数据评估咖啡诱导和/或咖啡因诱导的尿钠排泄对青年发病1型糖尿病（T1 D）（CKD高危人群）肾内血流动力学功能和肾能量学的影响。本研究选择了T1 D青少年患者，因为我们之前发现，与健康对照组相比，T1 D青少年患者表现出相对的肾缺氧，这与RPF增加、白蛋白尿和胰岛素抵抗相关，8因此使T1 D青少年患者成为针对肾小球内血流动力学功能障碍和肾缺氧作为未来DKD前体的治疗策略的理想焦点。
Coffee remains one of the most widely consumed beverages in the United States with an estimated 400 million cups ingested daily. 1 Extensive studies have revealed a wide variety of health benefits attributed to coffee consumption, and in a meta-analysis of 3 large prospective studies involving 208,501 adults, consumption of both caffeinated and decaffeinated coffee was associated with a lower risk of all-cause mortality. 2 One potential explanation for the survival benefit of coffee consumption is protection against kidney disease. Indeed, habitual coffee consumption was associated with a lower incidence of chronic kidney disease (CKD) in the Atherosclerosis in Communities study, a large population-based study of 14,209 older adults. 3 Yet, the specific physiological effects of coffee on kidney function that may contribute to improvements in morbidity and mortality have not yet been elucidated.Regular coffee contains multiple potential kidney-modifying compounds, including caffeine, a methylxanthine alkaloid which acts as an antagonist of the adenosine receptor, 4 and polyphenol bioactive compounds, which serve as plant-based antioxidants. 5 Caffeine has been found to modify kidney hemodynamics and natriuresis through factors including inhibition of proximal and distal tubule sodium reabsorption to promote free water and solute excretion and modification of the renin-angiotensin-aldosterone system. 4, 6 In response to sodium delivery to the distal tubule, caffeine has also been hypothesized to inhibit the tubuloglomerular feedback response and may maintain glomerular filtration rate (GFR) and renal plasma flow (RPF) while concurrently reducing consumption of renal oxygen (O 2). In conjunction with the beneficial effects of caffeine, bioactive compounds in coffee have also been found to improve oxidative stress and inflammation, known contributing factors for kidney injury. 5, 7 However, to date, there are no data evaluating the influence of coffee-induced and/or caffeine-induced natriuresis on intrarenal hemodynamic function and renal energetics in youth-onset type 1 diabetes (T1D), a population at high risk for CKD. Youth with T1D were selected for this study as we have previously found that adolescents with T1D exhibit relative renal hypoxia when compared with healthy controls and this is associated with increased RPF, albuminuria, and insulin resistance, 8 thus making youth with T1D an ideal focus for therapeutic strategies targeting intraglomerular hemodynamic dysfunction and renal hypoxia as precursors for future DKD.
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DOI：
10.1053/j.ajkd.2018.01.030
发表时间：
2018-08
期刊：
American journal of kidney diseases : the official journal of the National Kidney Foundation
影响因子：
--
作者：
Hu EA;Selvin E;Grams ME;Steffen LM;Coresh J;Rebholz CM
通讯作者：
Rebholz CM
影响因子：
19.6
作者：
Pruijm, Menno;Milani, Bastien;Burnier, Michel
通讯作者：
Burnier, Michel
影响因子：
11.4
作者：
Sureshbabu A;Ryter SW;Choi ME
通讯作者：
Choi ME
影响因子：
6
作者：
PASSMORE, AP;KONDOWE, GB;JOHNSTON, GD
通讯作者：
JOHNSTON, GD
影响因子：
8.3
作者：
BROWN, NJ;RYDER, D;NADEAU, J
通讯作者：
NADEAU, J