Coffee Consumption and Incident Kidney Disease: Results From the Atherosclerosis Risk in Communities (ARIC) Study.
Coffee Consumption and Incident Kidney Disease: Results From the Atherosclerosis Risk in Communities (ARIC) Study.
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DOI：
10.1053/j.ajkd.2018.01.030
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发表时间：
2018-08
期刊：
影响因子：
--
通讯作者：
Rebholz CM
中科院分区：
文献类型：
--
作者：
Hu EA;Selvin E;Grams ME;Steffen LM;Coresh J;Rebholz CM
适量饮用咖啡被认为与患慢性疾病（如糖尿病，慢性肾脏病（CKD）的主要前期疾病）的风险较低有关。然而，咖啡与慢性肾脏病之间的关联尚未完全确定。
前瞻性队列研究。
来自社区动脉粥样硬化风险（ARIC）研究的14209名年龄在45 - 64岁的参与者。
在第1次随访（1987 - 1989年）和第3次随访（1993 - 1995年）时使用食物频率问卷评估咖啡摄入量（杯/天）。
将发生慢性肾脏病定义为估算肾小球滤过率（eGFR）<60 mL/min/1.73 m²，同时伴有eGFR下降≥25%、因慢性肾脏病相关原因住院或死亡，或终末期肾病。
在中位随访24年期间，共有3845例慢性肾脏病发生病例。男性、白人、当前吸烟者以及无合并症的参与者更有可能每天饮用较多的咖啡。在对人口统计学、临床和饮食因素进行调整后，与从不喝咖啡的人相比，较高的咖啡摄入量类别与慢性肾脏病发生风险较低有关[每天<1杯的风险比（HR）为0.90（95%置信区间，0.82 - 0.99）；每天1 - <2杯的为0.90（95%置信区间，0.82 - 0.99）；每天2 - <3杯的为0.87（95%置信区间，0.77 - 0.97）；每天≥3杯的为0.84（95%置信区间，0.75 - 0.94）]。在连续分析中，每天每多喝一杯咖啡，慢性肾脏病发生风险降低3%（HR为0.97；95%置信区间，0.95 - 0.99；p<0.001）。
自我报告的咖啡摄入量和观察性设计。
在对协变量进行调整后，饮用较多咖啡的参与者发生慢性肾脏病的风险较低。喝咖啡的人可能不会面临肾脏疾病的不利风险。
Moderate coffee consumption has been suggested to be associated with lower risk of chronic conditions such as diabetes, a major precursor to chronic kidney disease (CKD). However, the association between coffee and CKD has not been fully established. Prospective cohort study. 14,209 participants aged 45–64 years from the Atherosclerosis Risk in Communities (ARIC) Study. Coffee consumption (cups/day) was assessed at visit 1 (1987–89) and visit 3 (1993–95) using food frequency questionnaires. Incident CKD defined as eGFR <60 mL/min/1.73 m2 accompanied by ≥25% eGFR decline, CKD-related hospitalization or death, or end-stage renal disease. There were 3,845 cases of incident CKD over a median of 24 years of follow-up. Men, whites, current smokers, and participants without comorbidities were more likely to consume higher amounts of coffee per day. After adjustment for demographic, clinical, and dietary factors, higher categories of coffee consumption were associated with lower risk of incident CKD compared to those who never consume coffee [hazard ratio (HR) for <1 cup/day, 0.90 (95% CI, 0.82–0.99); for 1 to <2 cups/day, 0.90 (95% CI, 0.82–0.99); for 2 to <3 cups/day, 0.87 (95% CI, 0.77–0.97); and for ≥3 cups/day, 0.84 (95% CI, 0.75–0.94)]. In continuous analysis, for each additional cup of coffee consumed per day, the risk of incident CKD was lower by 3% (HR, 0.97; 95% CI, 0.95–0.99; p<0.001). Self-reported coffee consumption and observational design. Participants who drank higher amounts of coffee had a lower risk of incident CKD after adjusting for covariates. Coffee consumers may not be at adverse risk for kidney disease.
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影响因子：
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作者：
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DOI：
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发表时间：
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期刊：
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