Microscale Biomaterials with Bioinspired Complexity of Early Embryo Development and in the Ovary for Tissue Engineering and Regenerative Medicine.
Microscale Biomaterials with Bioinspired Complexity of Early Embryo Development and in the Ovary for Tissue Engineering and Regenerative Medicine.
复制标题
早期胚胎发育的生物启动复杂性以及组织工程和再生医学的生物启发的复杂性。
DOI：
10.1021/acsbiomaterials.6b00540
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发表时间：
2017
影响因子：
5.8
通讯作者：
He X
中科院分区：
文献类型：
--
作者：
He X
组织工程和再生医学（$TERM）在现代医学治疗各种疾病方面正受到越来越多的关注。已经开发了包括水凝胶和支架的各种生物材料以在3D条件下制备细胞（特别是干细胞）和组织用于TERM应用。虽然这些生物材料在早期的研究中通常是同质的，但最近已经做出努力来产生具有在所研究的特定细胞和组织的天然环境中存在的时空复杂性的生物材料。在这篇文章中，我们介绍了微流体和同轴电喷雾方法，我们用于生成具有女性生殖系统中的孵化前胚胎和卵巢的空间复杂性的微尺度生物材料。其次是概述了我们最近的工作，将所得的生物启发的生物材料用于培养正常和癌症干细胞，心脏组织再生和卵巢卵泡的培养。心脏再生研究显示了使用不同生物材料在不同阶段（即，体外培养与体内植入）用于组织再生。所有的研究都证明了在工程细胞和组织中为$TERM应用考虑生物启发的复杂性的优点。
Tissue engineering and regenerative medicine (TERM) are attracting more and more attention for treating various diseases in modern medicine. Various biomaterials including hydrogels and scaffolds have been developed to prepare cells (particularly stem cells) and tissues under 3D conditions for TERM applications. Although these biomaterials are usually homogeneous in early studies, effort has been made recently to generate biomaterials with the spatiotemporal complexities present in the native milieu of the specific cells and tissues under investigation. In this communication, the microfluidic and coaxial electrospray approaches that we used for generating microscale biomaterials with the spatial complexity of both pre-hatching embryos and ovary in the female reproductive system were introduced. This is followed by an overview of our recent work on applying the resultant bioinspired biomaterials for cultivation of normal and cancer stem cells, regeneration of cardiac tissue, and culture of ovarian follicles. The cardiac regeneration studies show the importance of using different biomaterials to engineer stem cells at different stages (i.e., in vitro culture versus in vivo implantation) for tissue regeneration. All the studies demonstrate the merit of accounting for bioinspired complexities in engineering cells and tissues for TERM applications.
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影响因子：
3.7
作者：
Choi JK;He X
通讯作者：
He X
DOI：
10.1126/science.1171396
发表时间：
2009-05-15
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Fan HY;Liu Z;Shimada M;Sterneck E;Johnson PF;Hedrick SM;Richards JS
通讯作者：
Richards JS
影响因子：
4.6
作者：
Cubaud, Thomas;Mason, Thomas G.
通讯作者：
Mason, Thomas G.
影响因子：
56.9
作者：
Cukierman, E;Pankov, R;Yamada, KM
通讯作者：
Yamada, KM
影响因子：
14
作者：
Choi, Jung Kyu;Agarvval, Pranay;Huang, Haishui;Zhao, Shuting;He, Xiaoming
通讯作者：
He, Xiaoming