The association between MICA/MICB polymorphism and respiratory syncytial virus infection in children
The association between MICA/MICB polymorphism and respiratory syncytial virus infection in children
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MICA/MICB多态性与儿童呼吸道合胞病毒感染的相关性
DOI：
10.1111/iji.12338
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发表时间：
2017-09
期刊：
影响因子：
--
通讯作者：
S. Peng
中科院分区：
文献类型：
--
作者：
Y. Zou;Q. Luo;X. Guo;S. Peng
云母/MICB基因多态性与多种癌症和感染性疾病有关，但与呼吸道合胞病毒（RSV）感染的相关性尚未见报道。为了阐明云母/MICB基因多态性与儿童RSV感染之间的关系，我们收集了RSV感染后有肺炎和无肺炎的儿科患者的新鲜血液样本。采用序列特异性引物聚合酶链反应（PCR-SSP）和基于序列的聚合酶链反应（PCR-SBT）技术检测云母/MICB等位基因，计算云母/MICB等位基因频率和单倍型频率。结果表明，云母 *002：01和MICA-A9在RSV感染患者中的频率显著低于对照组（9%对20%，pc = 0.04）。云母 *002：01等位基因频率在肺炎组（8%）和非肺炎组（9%）均显著低于对照组（20%，pc = 0.02），在RSV感染者中云母 *002：01-MICB*008（Δrel = 0.616）、云母 *009-MICB*016（Δrel = 0.506）和云母 *045-MICB*014（Δrel = 0.700）呈连锁不平衡。RSV感染患者中MICA*002：01-MICB*005：02的单倍型频率显著低于对照组（10% vs. 16%，pc = 0.033）。因此，等位基因云母 *002：01/A9和单倍型云母 *002：01-MICB*005：02与RSV呼吸道感染呈负相关。
MICA/MICB gene polymorphisms are related to several cancers and infectious diseases, but there are no reports on the association between MICA/MICB gene polymorphisms and respiratory syncytial virus (RSV) infection. To clarify the association between MICA/MICB gene polymorphisms and infection of RSV in children, we collected fresh blood samples from paediatric patients with and without pneumonia after RSV infection. The MICA/MICB alleles were characterized by PCR sequence-specific primers (PCR-SSP) and PCR sequence-based genotyping (PCR-SBT), and then, the frequency of the MICA/MICB alleles and haplotypes was calculated. The results showed that the frequencies of MICA*002:01 and MICA-A9 in RSV-infected patients were significantly lower than in controls (9% vs. 20%, pc = 0.04). The allele frequency of MICA*002:01 in pneumonia patients (8%) and nonpneumonia patients (9%) was significantly lower than in controls (20%,pc = 0.02).MICA*002:01-MICB*008(Δrel = 0.616), MICA*009-MICB*016 (Δrel = 0.506), and MICA*045-MICB*014 (Δrel = 0.700) showed linkage disequilibrium in patients infected with RSV. The haplotype frequency of MICA*002:01-MICB*005:02 in RSV-infected patients was significantly lower than in controls (10% vs. 16%, pc = 0.033). In conclusion, allele MICA*002:01/A9 and haplotype MICA*002:01-MICB*005:02 were negatively associated with RSV respiratory tract infections.
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