Arterial-renal Syndrome in Patients with ESRD, a New Disease Paradigm.
Arterial-renal Syndrome in Patients with ESRD, a New Disease Paradigm.
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ESRD患者，一种新疾病范式的患者中的动脉肾脏综合征。
DOI：
10.1177/10760296211072820
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发表时间：
2022-01
期刊：
影响因子：
--
通讯作者：
Fareed J
中科院分区：
文献类型：
--
作者：
Goldstein J;Dieter RS;Bansal V;Wieschhaus K;Dieter RS 2nd;Bontekoe E;Hoppensteadt D;Fareed J
终末期肾病（ESRD）患者常伴有心血管疾病的风险增加。心血管健康受损的情况，如心房颤动（AFIB）和外周动脉疾病（PAD），可能以一种反映ESRD恶化的方式改变生物标志物水平。本研究描述了ESRD患者内皮功能障碍的生物标志物和实验室参数，并根据附加AFIB和PAD条件进行分类。收集95例ESRD患者的柠檬酸血样本。使用夹心elisa从血浆样品中测量生物标志物水平，包括组织纤溶酶原激活物（tPA）、d -二聚体和硝基酪氨酸。实验室参数包括BUN、钙、肌酐、甲状旁腺激素、磷酸盐、碱性磷酸酶、铁蛋白、转铁蛋白和总铁容量，以及患者的合并症。合并症是通过提供者的说明和适用测试的证据来确定的。14.89%的患者存在心房颤动（n = 14）， 30.85%的患者存在外周动脉病变（n = 29）， 6.38%的患者存在外周动脉病变和心房颤动（n = 6）。与仅ESRD患者相比，ESRD和PAD患者的d -二聚体（p = 0.014）和硝基酪氨酸（p = 0.0330）水平升高。与仅ESRD患者相比，房颤患者的d -二聚体水平升高(p =。0372)，硝基酪氨酸(p =。0322)和tPA （p = 0.0198）。与单纯ESRD患者相比，合并PAD患者的硝基酪氨酸和d -二聚体水平升高；而伴有Afib的患者，其硝基酪氨酸、d -二聚体和tPA水平升高。
Patients with end-stage renal disease (ESRD) often present with an increased risk of cardiovascular disease. Conditions of compromised cardiovascular health such as atrial fibrillation (AFIB) and peripheral arterial disease (PAD) may alter biomarker levels in a way that reflects worsening ESRD. This study profiled biomarkers and laboratory parameters of endothelium dysfunction in patients with ESRD, categorized by additional AFIB and PAD conditions. Citrated blood samples were collected from 95 patients with ESRD. Biomarker levels were measured from plasma samples using sandwich ELISAs, including tissue plasminogen activator (tPA), D-dimer, and nitrotyrosine. Lab parameters, including BUN, calcium, creatinine, parathyroid hormone, phosphate, alkaline phosphatase, ferritin, transferrin, and total iron capacity, and patient comorbidities were obtained from patient medical records. The comorbidities were determined through provider notes, and evidence of applicable testing. 14.89% of patients were found to have atrial fibrillation (n = 14), 30.85% of patients were found to have peripheral arterial disease (n = 29), and 6.38% of patients were found to have both peripheral arterial disease and atrial fibrillation (n = 6). When compared to patients with only ESRD, patients with ESRD and PAD showed elevated levels of D-Dimer (p = .0314) and nitrotyrosine (p = .0330). When compared to patients with only ESRD, patients with atrial fibrillation showed elevated levels of D-Dimer (p = .0372), nitrotyrosine (p = .0322), and tPA (p = .0198). When compared to patients with just ESRD, patients with concomitant PAD had elevated levels of Nitrotyrosine and D-dimer; while patients with concomitant Afib had elevated levels of nitrotyrosine, D-dimer, as well as tPA.
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影响因子：
15.9
作者：
BRADLEY, SE;BRADLEY, GP
通讯作者：
BRADLEY, GP
影响因子：
2.9
作者：
Ronco, Claudio;Bellasi, Antonio;Di Lullo, Luca
通讯作者：
Di Lullo, Luca
影响因子：
19.6
作者：
RADEKE, HH;MEIER, B;RESCH, K
通讯作者：
RESCH, K
影响因子：
--
作者：
Virzì GM;Clementi A;de Cal M;Brocca A;Day S;Pastori S;Bolin C;Vescovo G;Ronco C
通讯作者：
Ronco C
影响因子：
3.7
作者：
Major RW;Cheng MRI;Grant RA;Shantikumar S;Xu G;Oozeerally I;Brunskill NJ;Gray LJ
通讯作者：
Gray LJ