Left ventricular filling in arterial hypertension. Influence of obesity and hemodynamic and structural confounders.
Left ventricular filling in arterial hypertension. Influence of obesity and hemodynamic and structural confounders.
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动脉高血压时左心室充盈。
DOI：
10.1161/01.hyp.29.2.544
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发表时间：
1997
期刊：
影响因子：
8.3
通讯作者：
Franco Contaldo
中科院分区：
文献类型：
--
作者：
G. Mureddu;Giovanni de Simone;R. Greco;Giuseppe Rosato;Franco Contaldo
应用多普勒超声心动图对80例正常血压者左室充盈与负荷及几何构型的关系进行了研究（40名正常体重[36 +/- 12岁，24名女性]和40名肥胖[35 +/- 13岁，24名女性]）和61名无症状冠心病的高血压受试者（29名正常体重[43 +/- 13岁，15名女性]和32名肥胖[42 +/- 13岁，19名女性]）和相当的左心室中壁性能。左心室质量除以身高的2.7次方在所有组中均高于血压正常的正常体重受试者（均P <0.0001），高血压肥胖受试者高于血压正常的肥胖受试者（P <0.001）。在控制年龄、性别、血压和心率后，与血压正常的正常体重受试者相比，高血压受试者和血压正常的肥胖受试者的等容舒张时间延长（均P < .0001）。体重指数、左心室尺寸和质量、收缩末期周向应力对这些差异无影响。在合并组中，等容舒张时间延长是由高平均血压预测的（β = 0.52，P < .001），收缩末期应力低（β =-0.33，P < .001），左心室质量增加（β = 0.24，P <0.004）和高体重指数（β = 0.14，P <0.05，多个R = 0.72，SEE = 16.5毫秒，P <0.0001）。在控制左心室质量后，早期二尖瓣血流速度峰值、早期充盈速度减速时间和早期与晚期左心室充盈比率的组间差异消失。因此，（1）在动脉高血压和肥胖中等容舒张时间均延长;（2）肥胖的存在不会显著增加高血压的等容舒张时间;（3）在控制左心室质量后，动脉高血压的左心室充盈异常被抵消。
We assessed the relations of left ventricular filling to load and geometry by Doppler echocardiography in 80 normotensive subjects (40 normal-weight [36 +/- 12 years, 24 women] and 40 obese [35 +/- 13 years, 24 women]) and 61 hypertensive subjects without silent coronary heart disease (29 normal-weight [43 +/- 13 years, 15 women] and 32 obese [42 +/- 13 years, 19 women]) and comparable left ventricular midwall performance. Left ventricular mass divided by height to the 2.7 power was higher in all groups than in normotensive normal-weight subjects (all P < .0001) and in hypertensive than normotensive obese subjects (P < .001). After controlling for age, sex, blood pressure, and heart rate, isovolumic relaxation time was prolonged in hypertensive subjects and normotensive obese subjects compared with normotensive normal-weight subjects (all P < .0001). Body mass index, left ventricular dimension and mass, and circumferential end-systolic stress did not influence these differences. In pooled groups, prolonged isovolumic relaxation time was predicted by high mean blood pressure (beta = 0.52, P < .001), low end-systolic stress (beta = -0.33, P < .001), increased left ventricular mass (beta = 0.24, P < .004), and high body mass index (beta = 0.14, P < .05, multiple R = .72, SEE = 16.5 milliseconds, P < .0001). Between-group differences in peak early transmitral flow velocity, the deceleration time of early filling velocity, and the ratio of early to late left ventricular filling disappeared after controlling for left ventricular mass. Thus, (1) isovolumic relaxation time is prolonged in both arterial hypertension and obesity; (2) the presence of obesity does not significantly increase isovolumic relaxation time in hypertension; and (3) abnormalities of left ventricular filling in arterial hypertension are offset after controlling for left ventricular mass.
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DOI：
10.1016/0735-1097(94)90390-5
发表时间：
1994-05-01
影响因子：
24
作者：
DESIMONE, G;DEVEREUX, RB;LARAGH, JH
通讯作者：
LARAGH, JH
DOI：
10.1016/0735-1097(92)90385-z
发表时间：
1992-11-01
影响因子：
24
作者：
DESIMONE, G;DANIELS, SR;ALDERMAN, MH
通讯作者：
ALDERMAN, MH
DOI：
10.1016/0735-1097(95)00282-8
发表时间：
1995-10-01
影响因子：
24
作者：
OLIVETTI, G;GIORDANO, G;ANVERSA, P
通讯作者：
ANVERSA, P
DOI：
10.1016/0735-1097(94)00540-7
发表时间：
1995-04-01
影响因子：
24
作者：
DESIMONE, G;DEVEREUX, RB;LARAGH, JH
通讯作者：
LARAGH, JH
左心室充盈异常：轻至中度全身性高血压的早期发现。
DOI：
10.1016/0002-9149(84)90695-7
发表时间：
1984
期刊：
The American journal of cardiology
影响因子：
--
作者：
Inouye,I;Massie,B;Loge,D;Topic,N;Silverstein,D;Simpson,P;Tubau,J
通讯作者：
Tubau,J