The coexistence of asthma and chronic obstructive pulmonary disease (COPD): prevalence and risk factors in young, middle-aged and elderly people from the general population.
The coexistence of asthma and chronic obstructive pulmonary disease (COPD): prevalence and risk factors in young, middle-aged and elderly people from the general population.
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DOI：
10.1371/journal.pone.0062985
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Verlato G
中科院分区：
文献类型：
--
作者：
de Marco R;Pesce G;Marcon A;Accordini S;Antonicelli L;Bugiani M;Casali L;Ferrari M;Nicolini G;Panico MG;Pirina P;Zanolin ME;Cerveri I;Verlato G
哮喘和慢性阻塞性肺疾病(COPD)的共同分布还没有得到很好的描述。这项研究的目的是确定医生自我报告的哮喘、COPD和哮喘-COPD重叠综合征的患病率，并评估这些情况是否共享一组共同的危险因素。在多中心呼吸系统疾病基因环境交互作用研究框架内，通过邮寄或电话对20-44岁(n = 5163)、45-(n = 2167)和65-84(n = 1030)的意大利普通人群进行了关于呼吸道症状、诊断和危险因素的筛查问卷。65岁和65-84岁的受试者中，分别有13%和21%的人被医生诊断为哮喘或慢性阻塞性肺疾病(肺气肿/慢性支气管炎/COPD)。老龄化与确诊的哮喘患病率显著下降(从8.2%降至1.6%)和确诊的COPD患病率显著上升(从3.3%升至13.3%)有关。20~44岁、45~和65~84岁年龄组哮喘和COPD重叠患病率分别为1.6%(1.3%~2.0%)、2.1%(1.5%~2.8%)和4.5%(3.2%~5.9%)。与仅有哮喘或COPD诊断的受试者相比，同时有哮喘和COPD诊断的受试者更有可能有呼吸道症状、身体损伤和住院报告(p<；0.01)。年龄、性别、教育程度和吸烟与这三种情况表现出不同的、有时是相反的关联。哮喘和慢性阻塞性肺病在普通人群中很常见，并且在相当大比例的受试者中共存。哮喘-COPD重叠综合征是一种重要的临床表型，值得更多的医学关注和进一步研究。
The joint distribution of asthma and chronic obstructive pulmonary disease (COPD) has not been well described. This study aims at determining the prevalence of self-reported physician diagnoses of asthma, COPD and of the asthma-COPD overlap syndrome and to assess whether these conditions share a common set of risk factors. A screening questionnaire on respiratory symptoms, diagnoses and risk factors was administered by mail or phone to random samples of the general Italian population aged 20–44 (n = 5163) 45–64 (n = 2167) and 65–84 (n = 1030) in the frame of the multicentre Gene Environment Interactions in Respiratory Diseases (GEIRD) study. A physician diagnosis of asthma or COPD (emphysema/chronic bronchitis/COPD) was reported by 13% and 21% of subjects aged <65 and 65–84 years respectively. Aging was associated with a marked decrease in the prevalence of diagnosed asthma (from 8.2% to 1.6%) and with a marked increase in the prevalence of diagnosed COPD (from 3.3% to 13.3%). The prevalence of the overlap of asthma and COPD was 1.6% (1.3%–2.0%), 2.1% (1.5%–2.8%) and 4.5% (3.2%–5.9%) in the 20–44, 45–64 and 65–84 age groups. Subjects with both asthma and COPD diagnoses were more likely to have respiratory symptoms, physical impairment, and to report hospital admissions compared to asthma or COPD alone (p<0.01). Age, sex, education and smoking showed different and sometimes opposite associations with the three conditions. Asthma and COPD are common in the general population, and they coexist in a substantial proportion of subjects. The asthma-COPD overlap syndrome represents an important clinical phenotype that deserves more medical attention and further research.
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DOI：
10.1016/j.jaci.2011.06.048
发表时间：
2011-09
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Hanania NA;King MJ;Braman SS;Saltoun C;Wise RA;Enright P;Falsey AR;Mathur SK;Ramsdell JW;Rogers L;Stempel DA;Lima JJ;Fish JE;Wilson SR;Boyd C;Patel KV;Irvin CG;Yawn BP;Halm EA;Wasserman SI;Sands MF;Ershler WB;Ledford DK;Asthma in Elderly workshop participants
通讯作者：
Asthma in Elderly workshop participants
影响因子：
14.2
作者：
Gershon, Andrea;Guan, Jun;To, Teresa
通讯作者：
To, Teresa
影响因子：
24.3
作者：
de Marco, R.;Cappa, V.;Verlato, G.
通讯作者：
Verlato, G.
影响因子：
4.3
作者：
Cazzola, Mario;Puxeddu, Ermanno;Calzetta, Luigino
通讯作者：
Calzetta, Luigino
DOI：
10.1164/rccm.200603-381oc
发表时间：
2007-01-01
影响因子：
24.7
作者：
de Marco, Roberto;Accordini, Simone;Burney, Peter
通讯作者：
Burney, Peter