New Insight into microRNA Functions in Cancer: Oncogene-microRNA-Tumor Suppressor Gene Network.
New Insight into microRNA Functions in Cancer: Oncogene-microRNA-Tumor Suppressor Gene Network.
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DOI：
10.3389/fmolb.2017.00046
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发表时间：
2017
影响因子：
5
通讯作者：
Cao Y
中科院分区：
文献类型：
--
作者：
Zhou K;Liu M;Cao Y
Tumorigenesis is a multi-step and complex process with multi-factors involved. Deregulated oncogenes and tumor suppressor genes (TSGs) induced by genetic and epigenetic factors are considered as the driving force in the development and progression of cancer. Besides, microRNAs (miRNAs) act vital roles in tumorigenesis through regulating some oncogenes and TSGs. Interestingly, miRNAs are also regulated by oncogenes and TSGs. Considering the entangled regulation, here we propose a new insight into these regulation relationships in cancer: oncogene–miRNA–TSG network, which further emphasizes roles of miRNA, as well as highlights the network regulation among oncogene, miRNA, and TSG during tumorigenesis. The oncogene–miRNA–TSG network demonstrates that oncogenes and TSGs not only show functional synergy, but also there are regulatory relationships among oncogenes and TSGs during tumorigenesis, which could be mediated by miRNAs. In view of the oncogene–miRNA–TSG network involved in many oncogenes, miRNAs, and TSGs, as well as occurring in various tumor types, the anomaly of this network may be a common event in cancers and participates in tumorigenesis. This hypothesis broadens horizons of molecular mechanisms underlying tumorigenesis, and may provide a new promising venue for the prediction, diagnosis, and even therapy of cancer.
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DOI：
10.1186/2043-9113-3-6
发表时间：
2013-03-16
期刊：
Journal of clinical bioinformatics
影响因子：
--
作者：
Kala R;Peek GW;Hardy TM;Tollefsbol TO
通讯作者：
Tollefsbol TO
影响因子：
3.2
作者：
Hong, Bo;van den Heuvel, A. Pieter J.;El-Deiry, Wafik S.
通讯作者：
El-Deiry, Wafik S.
影响因子：
5.3
作者：
Kumar, Premlata;Luo, Yanmin;Mendelson, Carole R.
通讯作者：
Mendelson, Carole R.
影响因子：
4.6
作者：
Kumari B;Jain P;Das S;Ghosal S;Hazra B;Trivedi AC;Basu A;Chakrabarti J;Vrati S;Banerjee A
通讯作者：
Banerjee A
影响因子：
2.3
作者：
Campaner S;Amati B
通讯作者：
Amati B