Functional brain networks involved in decision-making under certain and uncertain conditions.
Functional brain networks involved in decision-making under certain and uncertain conditions.
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DOI：
10.1007/s00234-017-1949-1
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发表时间：
2018-01
期刊：
影响因子：
2.8
通讯作者：
Killiany RJ
中科院分区：
文献类型：
--
作者：
Farrar DC;Mian AZ;Budson AE;Moss MB;Killiany RJ
本研究的目的是描述不确定条件下正常个体决策的成像标记，以便提供基线活动来比较病理状态下受损的决策。在这项横断面研究中，19名年龄在18-35岁的健康受试者使用菲利普斯T3扫描仪和32通道头线圈完成了一项新颖的决策卡片匹配任务。在6次功能运行中收集功能数据。在任务的一个条件下，参与者确定匹配卡片的规则；在另一种情况下，参与者是不确定的。我们使用FSL fMRI专家分析工具对两种情况进行聚类比较，并使用MATLAB进行基于网络的分析。不确定的>确定的比较产生了三个簇——一个中线簇，延伸到中脑、丘脑、双侧前额叶皮层、纹状体和双侧顶叶/枕叶簇。某些>不确定比较在脑岛、顶叶和颞叶产生双侧簇，以及内侧额叶簇。在不确定条件下，发现了一个更大、更连通的功能网络。特定条件下的脑岛、顶叶皮层、颞叶皮层、腹内侧前额叶皮层和眼窝额叶皮层的参与强化了确定性本身就是有益的这一概念。在不确定条件下，前额叶皮层、顶叶皮层、纹状体、丘脑、杏仁核和海马体参与，因为这些区域涉及解决不确定性和规则更新。枕皮质受累和中脑受累可归因于视觉注意和运动控制的增加。
The aim of this study was to describe imaging markers of decision-making under uncertain conditions in normal individuals, in order to provide baseline activity to compare to impaired decision-making in pathological states. In this cross-sectional study, 19 healthy subjects ages 18–35 completed a novel decision-making card-matching task using a Phillips T3 Scanner and a 32-channel head coil. Functional data were collected in six functional runs. In one condition of the task, the participant was certain of the rule to apply to match the cards; in the other condition, the participant was uncertain. We performed cluster-based comparison of the two conditions using FSL fMRI Expert Analysis Tool and network-based analysis using MATLAB. The uncertain > certain comparison yielded three clusters—a midline cluster that extended through the midbrain, the thalamus, bilateral prefrontal cortex, the striatum, and bilateral parietal/occipital clusters. The certain > uncertain comparison yielded bilateral clusters in the insula, parietal and temporal lobe, as well as a medial frontal cluster. A larger, more connected functional network was found in the uncertain condition. The involvement of the insula, parietal cortex, temporal cortex, ventromedial prefrontal cortex, and orbitofrontal cortex of the certain condition reinforces the notion that certainty is inherently rewarding. For the uncertain condition, the involvement of the prefrontal cortex, parietal cortex, striatum, thalamus, amygdala, and hippocampal involvement was expected, as these are areas involved in resolving uncertainty and rule updating. The involvement of occipital cortical involvement and midbrain involvement may be attributed to increased visual attention and increased motor control.
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发表时间：
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影响因子：
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