Increased functional connectivity between dorsal posterior parietal and ventral occipitotemporal cortex during uncertain memory decisions.
Increased functional connectivity between dorsal posterior parietal and ventral occipitotemporal cortex during uncertain memory decisions.
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DOI：
10.1016/j.nlm.2014.04.015
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发表时间：
2015-01
影响因子：
2.7
通讯作者：
Wagner, Anthony D.
中科院分区：
文献类型：
--
作者：
Hutchinson, J. Benjamin;Uncapher, Melina R.;Wagner, Anthony D.
情节记忆的提取是一个多组分的行为，它依赖于许多操作，从处理提取线索，评估检索的信息，到根据任务的要求选择适当的反应。在丰富的功能神经成像文献的推动下，最近关于提取的各种计算的理论集中在后顶叶皮质(PPC)的作用上。在一个潜在的有希望的研究领域，最近的神经成像发现表明，背侧PPC的不同亚区对提取决定的不同方面做出了不同的反应，这表明更好地理解它们的贡献可能有助于揭示提取的组成部分过程。为了了解背侧PPC执行的基本操作，我们使用功能磁共振成像和功能连接性分析来研究代表提取线索的背侧PPC和腹侧颞区的激活和连接如何随着提取决策的不确定性而变化。具体地说，受试者对一系列视觉呈现的新旧单词进行了五分识别信心判断。与之前的研究一致，记忆相关的活动模式在左侧背侧PPC亚区分离，外侧IPS的活动跟踪参与者认为物品过时的程度，而SPL的活动随着决策不确定性的增加而增加。重要的是，全脑功能连通性分析进一步表明，在不确定的情况下，相对于某些决定，SPL的活动与视觉词形区域的活动具有更强的相关性。这些数据表明，SPL在情景提取过程中的参与至少部分地反映了提取线索的加工，可能是为了增加由线索引发的助记证据的尝试。
Retrieval of episodic memories is a multi-component act that relies on numerous operations ranging from processing the retrieval cue, evaluating retrieved information, and selecting the appropriate response given the demands of the task. Motivated by a rich functional neuroimaging literature, recent theorizing about various computations at retrieval has focused on the role of posterior parietal cortex (PPC). In a potentially promising line of research, recent neuroimaging findings suggest that different subregions of dorsal PPC respond distinctly to different aspects of retrieval decisions, suggesting that better understanding of their contributions might shed light on the component processes of retrieval. In an attempt to understand the basic operations performed by dorsal PPC, we used functional MRI and functional connectivity analyses to examine how activation in, and connectivity between, dorsal PPC and ventral temporal regions representing retrieval cues varies as a function of retrieval decision uncertainty. Specifically, participants made a five-point recognition confidence judgment for a series of old and new visually presented words. Consistent with prior studies, memory-related activity patterns dissociated across left dorsal PPC subregions, with activity in the lateral IPS tracking the degree to which participants perceived an item to be old, whereas activity in the SPL increased as a function of decision uncertainty. Importantly, whole-brain functional connectivity analyses further revealed that SPL activity was more strongly correlated with that in the visual word-form area during uncertain relative to certain decisions. These data suggest that the involvement of SPL during episodic retrieval reflects, at least in part, the processing of the retrieval cue, perhaps in service of attempts to increase the mnemonic evidence elicited by the cue.
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影响因子：
16.2
作者：
Dobbins, IG;Foley, H;Wagner, AD
通讯作者：
Wagner, AD
影响因子：
3.7
作者：
Cansino, S;Maquet, P;Rugg, MD
通讯作者：
Rugg, MD
影响因子：
25
作者：
Eldridge, LL;Knowlton, BT;Engel, SA
通讯作者：
Engel, SA
DOI：
10.1523/jneurosci.3077-09.2010
发表时间：
2010-03-31
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Han S;Huettel SA;Raposo A;Adcock RA;Dobbins IG
通讯作者：
Dobbins IG
DOI：
10.1073/pnas.0603949103
发表时间：
2006-06-27
影响因子：
11.1
作者：
Heekeren HR;Marrett S;Ruff DA;Bandettini PA;Ungerleider LG
通讯作者：
Ungerleider LG